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Articles Published Processes
2/25/2022 12:19:16 PM | Browse: 346 | Download: 668
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Received |
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2021-02-23 10:30 |
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Peer-Review Started |
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2021-02-23 10:33 |
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To Make the First Decision |
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Return for Revision |
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2021-04-20 02:25 |
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Revised |
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2021-05-01 14:27 |
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Second Decision |
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2022-02-14 05:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-02-16 07:23 |
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Articles in Press |
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2022-02-16 07:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-21 02:03 |
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Publish the Manuscript Online |
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2022-02-25 12:19 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sophie Vanderstichele and Jan Jeroen Vranckx |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jan Jeroen Vranckx, MD, PhD, Professor, Department of Plastic, Reconstructive and Aesthetic Surgery, KU-Leuven University Hospitals, Department of Plastic, Reconstructive & Aesthetic Surgery, KU-Leuven University Hospitals, Herestraat 49, B-3000 Leuven, Belgium. Electronic address: jan.vranckx@uzleuven.be., Leuven 3000, Belgium. jan.vranckx@uzleuven.be |
| Key Words |
Fibrosis; Fat grafting; Adipose-derived stem cells; Angiogenesis; Anti-fibrotic effect; Immunomodulation |
| Core Tip |
The goal of this review is to elucidate the potential mechanisms of action of fat grafting, and more specifically of adipose-derived stem cells (ADSCs), in hostile environment. Why can fat grafts turn the sclerotic environment after intense radiotherapy, burns or surgical trauma into a soft zone that can be further restored and reconstructed? In doing so, this review aims to complement existing literature by delivering an integrated approach to explain the positive effect of ADSCs on fibrosis, considering all 3 main fibrotic aspects, i.e., extracellular matrix accumulation, innate and adaptive immune response and vascularization. It aims at acknowledging the complexity and reciprocal impact these aspects have, both from a clinical as well as a molecular point of view. While available literature so far only focused on a single one of these aspects, the question remains whether an integrated approach and explanation on these combined levels could improve the effectiveness and application areas of this treatment. |
| Publish Date |
2022-02-25 12:19 |
| Citation |
Vanderstichele S, Vranckx JJ. Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars. World J Stem Cells 2022; 14(2): 200-213 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i2/200.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i2.200 |
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