Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	6477
Country	Italy

Received	2013-10-20 22:16
Peer-Review Started	2013-10-22 14:26
To Make the First Decision	2013-12-13 13:32
Return for Revision	2013-12-17 12:23
Revised	2014-01-02 22:29
Second Decision	2014-01-16 14:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-16 14:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-24 23:24
Typeset the Manuscript	2014-05-08 20:27
Publish the Manuscript Online	2014-05-20 15:49

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Esophageal motility abnormalities in gastroesophageal reflux disease
Manuscript Source	Invited Manuscript
All Author List	Irene Martinucci, Nicola de Bortoli, Maria Giacchino, Santino Marchi, Vincenzo Savarino and Edoardo Savarino
Funding Agency and Grant Number
Corresponding Author	Edoardo Savarino, MD, PhD, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, 35128 Padua, Italy. edoardo.savarino@gmail.com
Key Words	Gastroesophageal reflux disease; High-resolution manometry; Ineffective esophageal motility; Esophagogastric junction; Transient lower esophageal sphincter relaxations
Core Tip	Esophageal motility abnormalities are among the main factors implicated in the pathogenesis of gastroesophageal reflux disease. In particular, transient lower esophageal sphincter (LES) relaxations, hypotensive LES, ineffective esophageal peristalsis and bolus transit abnormalities have been strongly implicated in gastroesophageal reflux disease development. Moreover, recent findings suggest that these abnormalities are increasingly prevalent with increasing severity of reflux disease. Currently, surgery represents the only reliable way to restore the esophagogastric junction integrity and to reduce transient LES relaxations. On that ground, more in depth future studies assessing the pathogenetic role of dysmotility in patients with reflux disease are warranted.
Publish Date	2014-05-20 15:49
Citation	Martinucci I, de Bortoli N, Giacchino M, Bodini G, Marabotto E, Marchi S, Savarino V, Savarino E. Esophageal motility abnormalities in gastroesophageal reflux disease. World J Gastrointest Phar­macol Ther 2014; 5(2): 86-96
URL	http://www.wjgnet.com/2150-5349/full/v5/i2/86.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v5.i2.86

Full Article (PDF)	WJGPT-5-86.pdf
Full Article (Word)	WJGPT-5-86.doc
Manuscript File	6477-Review.doc
Answering Reviewers	6477-Answering reviewers.pdf
Copyright License Agreement	6477-Copyright assignment.pdf
Peer-review Report	6477-Peer review(s).docx
Scientific Editor Work List	6477-Scientific editor work list.doc