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Articles Published Processes
10/15/2021 9:56:18 AM | Browse: 528 | Download: 789
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Received |
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2021-02-24 00:15 |
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Peer-Review Started |
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2021-02-24 00:18 |
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To Make the First Decision |
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Return for Revision |
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2021-07-04 02:37 |
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Revised |
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2021-07-19 07:07 |
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Second Decision |
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2021-08-25 03:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-25 05:45 |
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Articles in Press |
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2021-08-25 05:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-08 07:49 |
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Publish the Manuscript Online |
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2021-10-15 09:56 |
ISSN |
2220-3206 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Psychiatry |
Manuscript Type |
Review |
Article Title |
Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man
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Manuscript Source |
Invited Manuscript |
All Author List |
Gary R Hime, Sophie LA Stonehouse and Terence Y Pang |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Terence Y Pang, PhD, Senior Postdoctoral Fellow, Mental Health Theme, The Florey Institute of Neuroscience and Mental Health, 30 Royal Parade
, Parkville 3052, VIC, Australia. terence.pang@florey.edu.au |
Key Words |
Transgenerational inheritance; Epigenetics; Invertebrate models; Caenorhabditis elegans; Drosophila melanogaster; Environmental stress |
Core Tip |
Psychiatry research is only beginning to identify the complex epigenetic pathologies across various conditions that may regulate symptomatology. Epigenetics may account for certain conditions that are highly heritable but are not fully accounted for by genetics. Preclinical animal models are a necessary tool to accelerate our understanding of molecular mechanisms and for developing new therapeutic options. Simple behavioural and neurobiological assays combined with high levels of functional gene conservation and rapid generation time in easily genetically manipulated organisms make Caenorhabditis elegans and Drosophila melanogaster excellent systems to model transgenerational epigenetic inheritance phenotypes. |
Publish Date |
2021-10-15 09:56 |
Citation |
Hime GR, Stonehouse SLA, Pang TY. Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man. World J Psychiatr 2021; 11(10): 711-735 |
URL |
https://www.wjgnet.com/2220-3206/full/v11/i10/711.htm |
DOI |
https://dx.doi.org/10.5498/wjp.v11.i10.711 |
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