BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/25/2022 12:19:16 PM | Browse: 410 | Download: 819
 |
Received |
|
2021-02-28 09:26 |
|
Peer-Review Started |
|
2021-02-28 09:33 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2021-04-19 18:44 |
|
Revised |
|
2021-07-29 10:40 |
|
Second Decision |
|
2022-01-06 03:31 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2022-01-06 19:43 |
|
Articles in Press |
|
2022-01-06 19:43 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2021-12-11 20:11 |
|
Typeset the Manuscript |
|
2022-02-22 01:39 |
|
Publish the Manuscript Online |
|
2022-02-25 12:19 |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors and their in vivo implantation regenerated the intervertebral disc degeneration
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shumaila Khalid, Sobia Ekram, Asmat Salim, G Rasul Chaudhry and Irfan Khan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Higher Education Commission Pakistan |
7083 |
|
| Corresponding Author |
Irfan Khan, PhD, Assistant Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, KU Circular Rd, Karachi 75270, Sindh, Pakistan. khan@iccs.edu |
| Key Words |
Intervertebral Disc Degeneration; Human Umbilical Cord; Transcription Factors; Mesenchymal Stem Cells; Gene Expression; Regeneration |
| Core Tip |
In this study, we highlighted that overexpression of chondrogenic transcription factors in human umbilical cord derived mesenchymal stem cells (hUC-MSCs) accelerated their differentiation potential into chondroprogenitor cells. The synergistic effect of Sox-9, and Six-1 transcription factors leads the MSCs to differentiate into chondrogenic cells in the basal medium, which produced the same effect as the chondro-induction medium. The in vivo transplantation of these transfected cells leads to their homing, integration, and differentiation into nucleus pulposus cells of the intervertebral disc. Histological observation and grading score showed that the cellular transplanted group significantly regenerated the degenerated disc. This approach of manipulating stem cells in vitro and their transplantation in the degenerated disc could help to develop a better treatment option for treating degenerative disc diseases. |
| Publish Date |
2022-02-25 12:19 |
| Citation |
Khalid S, Ekram S, Salim A, Chaudhry GR, Khan I. Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors and their in vivo implantation regenerated the intervertebral disc degeneration. World J Stem Cells 2022; 14(2): 163-182 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i2/163.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i2.163 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
