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Articles Published Processes
7/15/2021 10:19:10 AM | Browse: 785 | Download: 1281
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Received |
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2021-02-27 07:27 |
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Peer-Review Started |
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2021-02-27 07:34 |
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To Make the First Decision |
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Return for Revision |
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2021-03-30 04:22 |
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Revised |
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2021-04-06 13:03 |
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Second Decision |
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2021-06-18 06:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-06-18 11:27 |
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Articles in Press |
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2021-06-18 11:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-07-14 03:48 |
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Publish the Manuscript Online |
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2021-07-15 10:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Review |
| Article Title |
Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Matej Ľupták, Danica Michaličková, Zdeněk Fišar, Eva Kitzlerová and Jana Hroudová |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant Agency of Charles University, Czech Republic |
34119 |
| Projects Progres of Charles University |
Q27/LF1 |
| Projects Progres of Charles University |
Q25/LF1 |
| Project Ministry of Health, Czech Republic for Conceptual Development of Research Organization |
64165 |
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| Corresponding Author |
Jana Hroudová, MD, PharmD, PhD, Associate Professor, Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Albertov 4, Prague 12000, Czech Republic. hroudova.jana@gmail.com |
| Key Words |
Schizophrenia; Immune system; Inflammation; Genetics; Novel antipsychotics; Add-on therapy |
| Core Tip |
This review discusses the newest insights in the pathophysiology and risk factors for schizophrenia and points out the novel approaches of antipsychotic treatment, potential diagnostic and theranostic biomarkers. The hypotheses focusing on neuromediators (dopamine, glutamate, serotonin), neuroinflammation, cannabinoid hypothesis, gut brain axis model, and other currently discussed hypotheses are summarized. Key genetic features and new findings in the pathophysiology of schizophrenia support the expansion of novel approaches in pharmacotherapy and development of non-dopaminergic antipsychotics. |
| Publish Date |
2021-07-15 10:19 |
| Citation |
Ľupták M, Michaličková D, Fišar Z, Kitzlerová E, Hroudová J. Novel approaches in schizophrenia-from risk factors and hypotheses to novel drug targets. World J Psychiatr 2021; 11(7): 277-296 |
| URL |
https://www.wjgnet.com/2220-3206/full/v11/i7/277.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v11.i7.277 |
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