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Articles Published Processes
11/15/2021 8:09:29 AM | Browse: 641 | Download: 1312
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Received |
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2021-02-25 09:18 |
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Peer-Review Started |
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2021-02-25 09:21 |
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First Decision by Editorial Office Director |
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2021-05-03 21:44 |
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Return for Revision |
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2021-05-03 21:44 |
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Revised |
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2021-05-27 14:56 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-22 03:18 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-23 07:37 |
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Articles in Press |
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2021-09-23 07:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-10 06:18 |
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Publish the Manuscript Online |
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2021-11-15 08:09 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Ling Chung, Yi-Chou Hou, I-Kuan Wang, Kuo-Cheng Lu and Tzung-Hai Yen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chang Gung Memorial Hospital, Linkou, Taiwan |
CORPG3K0191 |
| Chang Gung Memorial Hospital, Linkou, Taiwan |
CMRPG3J1051-3 |
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| Corresponding Author |
Tzung-Hai Yen, MD, PhD, Doctor, Doctor, Professor, Department of Nephrology, Chang Gung Memorial Hospital, No. 199 Tung Hwa North Road, Linkou 333, Taiwan. m19570@adm.cgmh.org.tw |
| Key Words |
Organophosphate; Pesticide; New-onset diabetes mellitus; Mechanism; Reactive oxygen species |
| Core Tip |
Organophosphate may induce acute hyperglycemia by damaging pancreatic cells and result in new-onset diabetes mellitus after chronic exposure to organophosphate compounds. Organophosphate-mediated new-onset diabetes mellitus might be mediated by a polymorphism of paraoxonase-1, which is associated with organophosphate elimination in hepatocytes. Pancreatic beta cell damage, excessive gluconeogenesis, hepatic steatosis, systemic inflammation and possibly sarcopenia all contribute to insulin resistance and therefore hyperglycemia. |
| Publish Date |
2021-11-15 08:09 |
| Citation |
Chung YL, Hou YC, Wang IK, Lu KC, Yen TH. Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective. World J Diabetes 2021; 12(11): 1818-1831 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i11/1818.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i11.1818 |
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