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Articles Published Processes
10/22/2021 1:53:28 PM | Browse: 478 | Download: 1236
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Received |
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2021-02-27 19:14 |
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Peer-Review Started |
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2021-02-27 19:24 |
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To Make the First Decision |
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Return for Revision |
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2021-04-20 16:24 |
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Revised |
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2021-05-04 10:05 |
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Second Decision |
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2021-08-27 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-27 09:28 |
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Articles in Press |
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2021-08-27 09:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-09-05 21:35 |
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Typeset the Manuscript |
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2021-10-20 06:22 |
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Publish the Manuscript Online |
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2021-10-22 13:53 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Direct modulation of hepatocyte hepcidin signaling by iron
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lin-Na Yu, Shi-Jin Wang, Cheng Chen, Vanessa Rausch, Omar Elshaarawy and Sebastian Mueller |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Deutche Forschungsgemeinschaft |
RA 2677/1-2 (to Mueller S) |
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| Corresponding Author |
Sebastian Mueller, PhD, Professor, Center for Alcohol Research and Salem Medical Center, University of Heidelberg, Zeppelinstraße 11-33, Heidelberg 69121, Germany. sebastian.mueller@urz.uni-heidelberg.de |
| Key Words |
Hepcidin/iron metabolism; Iron overload; Inflammation; Hypoxia; BMP/SMAD; STAT3 |
| Core Tip |
Hepcidin is paradoxically and strongly suppressed during hemolytic iron overload. Although various upstream regulators of hepcidin have been discovered, the direct iron sensing mechanisms by hepcidin remain obscure. This study investigated the direct effect of iron on hepcidin signaling and for the first time to show that iron directly blocks hepcidin transcription via bone morphogenetic protein/small mothers against decapentaplegic but not the STAT3 signaling in various established in vitro models of hepcidin signaling. |
| Publish Date |
2021-10-22 13:53 |
| Citation |
Yu LN, Wang SJ, Chen C, Rausch V, Elshaarawy O, Mueller S. Direct modulation of hepatocyte hepcidin signaling by iron. World J Hepatol 2021; 13(10): 1378-1393 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i10/1378.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i10.1378 |
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