Publication Name	World Journal of Hepatology
Manuscript ID	64923
Country	Spain

Received	2021-02-25 11:24
Peer-Review Started	2021-02-25 11:30
To Make the First Decision
Return for Revision	2021-03-29 16:24
Revised	2021-04-13 09:08
Second Decision	2022-01-28 03:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-29 07:12
Articles in Press	2022-01-29 07:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-15 09:28
Publish the Manuscript Online	2022-02-22 09:25

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Methodology
Manuscript Type	Review
Article Title	Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
Manuscript Source	Invited Manuscript
All Author List	Maria Martin-Grau, Vannina G Marrachelli and Daniel Monleon
ORCID	Author(s) ORCID Number Maria Martin-Grau http://orcid.org/0000-0002-8781-5952 Vannina G Marrachelli http://orcid.org/0000-0002-4097-3312 Daniel Monleon http://orcid.org/0000-0002-4803-1573
Funding Agency and Grant Number
Corresponding Author	Daniel Monleon, PhD, Professor, Department of Pathology, University of Valencia, Avda Blasco Ibañez 15, Valencia 46010, Spain. daniel.monleon@uv.es
Key Words	Non-alcoholic fatty liver disease; Liver disease; Rodent models; Metabolic profiling; Metabolomics; Biomarkers
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a spectrum of different diseases that starts with asymptomatic steatosis, continues with steatohepatitis, and can progress to fibrosis. Current knowledge suggests that NAFLD initiates and progresses through most of nine hallmarks. Animal models remain crucial for understanding the disease and for developing tools based on biological knowledge. Metabolomics seems a valid tool for studying metabolic pathways and organ crosstalk in NAFLD. In this review, we provide a brief introduction to NAFLD hallmarks, the five groups of animal models available for studying NAFLD and the potential role of metabolomics in the study of experimental NAFLD.
Publish Date	2022-02-22 09:25
Citation	Martin-Grau M, Marrachelli VG, Monleon D. Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn? World J Hepatol 2022; 14(2): 304-318
URL	https://www.wjgnet.com/1948-5182/full/v14/i2/304.htm
DOI	https://dx.doi.org/10.4254/wjh.v14.i2.304

Full Article (PDF)	WJH-14-304.pdf
Full Article (Word)	WJH-14-304.docx
Manuscript File	64923_Auto_Edited.docx
Answering Reviewers	64923-Answering reviewers.pdf
Audio Core Tip	64923-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64923-Conflict-of-interest statement.pdf
Copyright License Agreement	64923-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64923-Language certificate.pdf
Peer-review Report	64923-Peer-review(s).pdf
Scientific Misconduct Check	64923-Bing-Gao CC-2.png
Scientific Editor Work List	64923-Scientific editor work list.pdf
CrossCheck Report	64923-CrossCheck report.pdf