Publication Name	World Journal of Stem Cells
Manuscript ID	65130
Country	China

Received	2021-02-28 13:29
Peer-Review Started	2021-02-28 13:32
To Make the First Decision
Return for Revision	2021-05-05 15:24
Revised	2021-06-07 02:58
Second Decision	2021-11-02 03:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-03 01:33
Articles in Press	2021-11-03 01:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-18 06:25
Publish the Manuscript Online	2021-11-25 08:31

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics
Manuscript Source	Invited Manuscript
All Author List	Ying Liu, Lu Gan, Di-Xin Cui, Si-Han Yu, Yue Pan, Li-Wei Zheng and Mian Wan
ORCID	Author(s) ORCID Number Ying Liu http://orcid.org/0000-0002-1047-8468 Lu Gan http://orcid.org/0000-0002-8778-8595 Di-Xin Cui http://orcid.org/0000-0002-8102-9504 Si-Han Yu http://orcid.org/0000-0002-7740-2660 Yue Pan http://orcid.org/0000-0001-8197-869X Li-Wei Zheng http://orcid.org/0000-0002-0467-1720 Mian Wan http://orcid.org/0000-0002-3373-2836
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81800929 Sichuan Science and Technology Program 2019JDRC0096 National Natural Science Foundation of China 81771033 Clinical Research Project/Foundation of West China Hospital of Stomatology LCYJ2019-24
Corresponding Author	Mian Wan, DDS, PhD, Academic Fellow, Academic Research, Attending Doctor, Lecturer, Postdoctoral Fellow, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section of Renmin South Road, Chengdu 610041, Sichuan Province, China. mianwan@scu.edu.cn
Key Words	Dental pulp stem cells; Regenerative endodontics; Epigenetic regulation; Noncoding RNAs; Histone deacetylase inhibitor; DNA methyltransferase inhibitor
Core Tip	We review the role of epigenetic modifications during fate determination of dental pulp stem cells, highlighting cellular processes implicating proliferation, odontogenesis, angiogenesis, and neurogenesis that are tightly correlated with regenerative endodontics (RE). We emphasize the potential of epigenetic manipulation through enzyme inhibitors in RE and provide insights for future development in regaining dental pulp function.
Publish Date	2021-11-25 08:31
Citation	Liu Y, Gan L, Cui DX, Yu SH, Pan Y, Zheng LW, Wan M. Epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics. World J Stem Cells 2021; 13(11): 1647-1666
URL	https://www.wjgnet.com/1948-0210/full/v13/i11/1647.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i11.1647

Full Article (PDF)	WJSC-13-1647.pdf
Full Article (Word)	WJSC-13-1647.docx
Manuscript File	65130_Auto_Edited.docx
Answering Reviewers	65130-Answering reviewers.pdf
Audio Core Tip	65130-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65130-Conflict-of-interest statement.pdf
Copyright License Agreement	65130-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65130-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	65130-Language certificate.pdf
Peer-review Report	65130-Peer-review(s).pdf
Scientific Editor Work List	65130-Scientific editor work list.pdf
CrossCheck Report	65130-CrossCheck report.pdf