Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	65143
Country	Japan

Received	2021-03-06 05:47
Peer-Review Started	2021-03-06 05:49
First Decision by Editorial Office Director	2021-07-03 05:56
Return for Revision	2021-07-03 15:08
Revised	2021-07-26 10:40
Publication Fee Transferred
Second Decision by Editor	2021-09-14 03:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2021-09-17 01:47
Articles in Press	2021-09-17 01:47
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-09 03:30
Publish the Manuscript Online	2021-10-14 06:40

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Hideaki Miyamoto, Hideaki Naoe, Jun Morinaga, Kensuke Sakisaka, Sayoko Tayama, Kenshi Matsuno, Ryosuke Gushima, Masakuni Tateyama, Takashi Shono, Masanori Imuta, Satoru Miyamaru, Daizo Murakami, Yorihisa Orita and Yasuhito Tanaka
ORCID	Author(s) ORCID Number Hideaki Miyamoto http://orcid.org/0000-0002-4078-5231 Hideaki Naoe http://orcid.org/0000-0003-4274-8220 Jun Morinaga http://orcid.org/0000-0002-6196-6023 Kensuke Sakisaka http://orcid.org/0000-0002-2582-743X Sayoko Tayama http://orcid.org/0000-0002-7264-5671 Kenshi Matsuno http://orcid.org/0000-0001-6975-1521 Ryosuke Gushima http://orcid.org/0000-0001-8264-7307 Masakuni Tateyama http://orcid.org/0000-0003-1935-2797 Takashi Shono http://orcid.org/0000-0002-7577-2991 Masanori Imuta http://orcid.org/0000-0002-2747-6493 Satoru Miyamaru http://orcid.org/0000-0003-1008-6904 Daizo Murakami http://orcid.org/0000-0001-8668-800X Yorihisa Orita http://orcid.org/0000-0002-2803-9623 Yasuhito Tanaka http://orcid.org/0000-0002-2473-6966
Funding Agency and Grant Number
Corresponding Author	Yasuhito Tanaka, MD, Professor, Department of Gastroenterology and Hepatology, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. ytanaka@kumamoto-u.ac.jp
Key Words	Gastrointestinal imaging; Head and neck imaging; Gastrointestinal endoscope; Hypopharyngeal neoplasm; Oropharyngeal neoplasm; Endoscopic surgery
Core Tip	This is the first study to explore the detection modality of oropharyngeal and hypopharyngeal squamous cell carcinomas (SCC). In this study, 31.4% of pharyngeal SCCs (15.4% of oropharyngeal SCCs and 42.3% of hypopharyngeal SCCs) were detected by gastrointestinal endoscopy. The clinical characteristics of the lesions detected by gastrointestinal endoscopy include a higher proportion of asymptomatic cases, cTis-1 cases, cases with no lymph node metastasis and cases treated by endoscopic laryngo-pharyngeal surgery/endoscopic submucosal dissection, leading to a better prognosis. This study highlights the important role of gastrointestinal endoscopy in the early detection and treatment of SCC in the otolaryngology field.
Publish Date	2021-10-14 06:40
Citation	Miyamoto H, Naoe H, Morinaga J, Sakisaka K, Tayama S, Matsuno K, Gushima R, Tateyama M, Shono T, Imuta M, Miyamaru S, Murakami D, Orita Y, Tanaka Y. Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study. World J Gastrointest Endosc 2021; 13(10): 491-501
URL	https://www.wjgnet.com/1948-5190/full/v13/i10/491.htm
DOI	https://dx.doi.org/10.4253/wjge.v13.i10.491

Full Article (PDF)	WJGE-13-491.pdf
Full Article (Word)	WJGE-13-491.docx
STROBE Statement	65143-STROBE-Statement-revision.pdf
Manuscript File	65143_Auto_Edited.docx
Answering Reviewers	65143-Answering reviewers.pdf
Audio Core Tip	65143-Audio core tip.mp3
Biostatistics Review Certificate	65143-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	65143-Conflict-of-interest statement.pdf
Copyright License Agreement	65143-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	65143-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	65143-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	65143-Language certificate.pdf
Peer-review Report	65143-Peer-review(s).pdf
CrossCheck Report	65143-CrossCheck report.pdf