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Articles Published Processes
1/21/2022 8:16:14 AM | Browse: 418 | Download: 777
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Received |
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2021-04-07 07:09 |
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Peer-Review Started |
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2021-04-07 07:13 |
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To Make the First Decision |
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Return for Revision |
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2021-07-06 02:44 |
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Revised |
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2021-07-20 22:32 |
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Second Decision |
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2021-12-24 04:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-25 20:14 |
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Articles in Press |
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2021-12-25 20:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-17 02:28 |
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Publish the Manuscript Online |
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2022-01-21 08:16 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Targets of immunotherapy for hepatocellular carcinoma: An update
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vikrant Rai and Sandeep Mukherjee |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sandeep Mukherjee, FRCP (C), MD, Full Professor, Department of Medicine, Creighton University School of Medicine, Suite 401 Education Building, 7710 Mercy Road, Omaha, NE 68124, United States. sandeep.mukherjee@alegent.org |
| Key Words |
Hepatocellular carcinoma; Immunotherapy; Immune checkpoint inhibitors; Adoptive cell therapy; Oncolytic vaccines; Combination therapy |
| Core Tip |
A significant proportion of patients with hepatocellular carcinoma (HCC) present with advanced disease and therapeutic strategies for such patients are limited. The tumor microenvironment mediating immune response suppression, immune tolerance, and evasion further complicate the treatment in advanced HCC. The involvement of immune response in the pathogenesis of HCC makes immunotherapy an attractive approach for the treatment of advanced HCC. Further, the recent research with beneficial results with immune checkpoint inhibition, adoptive cell transfer therapy, tumor vaccines, and combinational therapies to boost the immune response of the tumor are in development and have been discussed here. |
| Publish Date |
2022-01-21 08:16 |
| Citation |
Rai V, Mukherjee S. Targets of immunotherapy for hepatocellular carcinoma: An update. World J Hepatol 2022; 14(1): 140-157 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i1/140.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i1.140 |
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