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Articles Published Processes
8/20/2021 5:46:25 AM | Browse: 354 | Download: 897
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Received |
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2021-03-01 06:31 |
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Peer-Review Started |
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2021-03-01 06:54 |
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To Make the First Decision |
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Return for Revision |
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2021-04-19 18:24 |
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Revised |
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2021-06-06 14:24 |
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Second Decision |
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2021-07-30 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-30 06:22 |
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Articles in Press |
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2021-07-30 06:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-08-19 03:07 |
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Publish the Manuscript Online |
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2021-08-20 05:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Regulators of liver cancer stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kai Liu and Jing-Hsiung James Ou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health Grants |
DK094652 |
| National Institutes of Health Grants |
AI148304 |
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| Corresponding Author |
Jing-Hsiung James Ou, PhD, Professor, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA 90033, United States. jamesou@usc.edu |
| Key Words |
Hepatocellular carcinoma; Liver cancer stem cells; Pluripotency transcription factors; Stem cell signaling; Genetic regulators; Epigenetic regulators |
| Core Tip |
Liver cancer stem cells (LCSCs) play a crucial role in the development of hepatocellular carcinoma (HCC), and their tumorigenicity and chemoresistance are major reasons as to why HCC is difficult to treat. LCSCs are regulated by a variety of factors. These factors include the network of pluripotency transcription factors, signaling pathways that regulate stem cells, genetic alterations that may be caused by mutations or viral factors, and epigenetic regulations including DNA methylation, histone methylation and micorRNAs. These factors together induce the cancer stem cell properties of hepatocytes and play a critical role in the development of LCSCs and HCC. |
| Publish Date |
2021-08-20 05:46 |
| Citation |
Liu K, Ou JHJ. Regulators of liver cancer stem cells. World J Stem Cells 2021; 13(8): 1127-1133 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i8/1127.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i8.1127 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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