Publication Name	World Journal of Stem Cells
Manuscript ID	65191
Country	United States

Received	2021-03-01 06:31
Peer-Review Started	2021-03-01 06:54
To Make the First Decision
Return for Revision	2021-04-19 18:24
Revised	2021-06-06 14:24
Second Decision	2021-07-30 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-07-30 06:22
Articles in Press	2021-07-30 06:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-08-19 03:07
Publish the Manuscript Online	2021-08-20 05:46

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Regulators of liver cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Kai Liu and Jing-Hsiung James Ou
ORCID	Author(s) ORCID Number Kai Liu http://orcid.org/0000-0001-6039-2681 Jing-Hsiung James Ou http://orcid.org/0000-0002-8274-5705
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health Grants DK094652 National Institutes of Health Grants AI148304
Corresponding Author	Jing-Hsiung James Ou, PhD, Professor, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA 90033, United States. jamesou@usc.edu
Key Words	Hepatocellular carcinoma; Liver cancer stem cells; Pluripotency transcription factors; Stem cell signaling; Genetic regulators; Epigenetic regulators
Core Tip	Liver cancer stem cells (LCSCs) play a crucial role in the development of hepatocellular carcinoma (HCC), and their tumorigenicity and chemoresistance are major reasons as to why HCC is difficult to treat. LCSCs are regulated by a variety of factors. These factors include the network of pluripotency transcription factors, signaling pathways that regulate stem cells, genetic alterations that may be caused by mutations or viral factors, and epigenetic regulations including DNA methylation, histone methylation and micorRNAs. These factors together induce the cancer stem cell properties of hepatocytes and play a critical role in the development of LCSCs and HCC.
Publish Date	2021-08-20 05:46
Citation	Liu K, Ou JHJ. Regulators of liver cancer stem cells. World J Stem Cells 2021; 13(8): 1127-1133
URL	https://www.wjgnet.com/1948-0210/full/v13/i8/1127.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i8.1127

Full Article (PDF)	WJSC-13-1127.pdf
Full Article (Word)	WJSC-13-1127.docx
Manuscript File	65191_Auto_Edited-YJP.docx
Answering Reviewers	65191-Answering reviewers.pdf
Audio Core Tip	65191-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65191-Conflict-of-interest statement.pdf
Copyright License Agreement	65191-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65191-Grant application form(s).pdf
Peer-review Report	65191-Peer-review(s).pdf
Scientific Misconduct Check	65191-Bing-Wang JL-1.jpg
Scientific Misconduct Check	65191-Scientific misconduct check.pdf
Scientific Editor Work List	65191-Scientific editor work list.pdf