Publication Name	World Journal of Gastroenterology
Manuscript ID	65267
Country	Mexico

Received	2021-03-02 17:53
Peer-Review Started	2021-03-02 18:06
To Make the First Decision
Return for Revision	2021-04-17 14:17
Revised	2021-06-04 02:31
Second Decision	2021-12-08 07:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-10 02:50
Articles in Press	2021-12-10 02:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-17 04:02
Publish the Manuscript Online	2021-12-24 09:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Emerging therapeutic options in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Jesus K Yamamoto-Furusho and Norma N Parra-Holguín
ORCID	Author(s) ORCID Number Jesus K Yamamoto-Furusho http://orcid.org/0000-0002-5247-5812 Norma N Parra-Holguín http://orcid.org/0000-0002-0570-1127
Funding Agency and Grant Number
Corresponding Author	Jesus K Yamamoto-Furusho, MD, MS, PhD, Chief Doctor, Director, Director, Full Professor, Gastroenterology Unit, Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Vasco de Quiroga 15, Colonia Belisario Domínguez sección XVI, Alcaldía Tlalpan, Mexico City 14080, Mexico. kazuofurusho@hotmail.com
Key Words	Inflammatory bowel disease; Review; Emerging; Treatment; Ulcerative colitis; Crohn´s disease
Core Tip	This review is to present the efficacy and safety of novel treatments for inflammatory bowel disease. The new treatments that may be available in the future are new anti-tumor necrosis factor alpha, anti-integrines, anti-interleukines, modulation of sphingosine-1-phosphate, janus kinase inhibitors, toll like receptor agonist, therapy on the integrity of the epithelial barrier, phosphodiesterase-4 inhibitors and antisense oligonucleotide therapy, currently in clinical studies. Many of them with encouraging results in clinical studies, while others have not been able to maintain significant results in the final phases.
Publish Date	2021-12-24 09:48
Citation	Yamamoto-Furusho JK, Parra-Holguín NN. Emerging therapeutic options in inflammatory bowel disease. World J Gastroenterol 2021; 27(48): 8242-8261
URL	https://www.wjgnet.com/1007-9327/full/v27/i48/8242.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i48.8242

Full Article (PDF)	WJG-27-8242.pdf
Full Article (Word)	WJG-27-8242.docx
Manuscript File	65267_Auto_Edited.docx
Answering Reviewers	65267-Answering reviewers.pdf
Audio Core Tip	65267-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65267-Conflict-of-interest statement.pdf
Copyright License Agreement	65267-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65267-Language certificate.pdf
Peer-review Report	65267-Peer-review(s).pdf
Scientific Misconduct Check	65267-Bing-Wang JL-1.jpg
Scientific Editor Work List	65267-Scientific editor work list.pdf
CrossCheck Report	65267-CrossCheck report.pdf