BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/18/2021 8:08:20 AM | Browse: 648 | Download: 2189
 |
Received |
|
2021-03-03 13:55 |
|
Peer-Review Started |
|
2021-03-03 13:59 |
|
First Decision by Editorial Office Director |
|
2021-04-17 13:53 |
|
Return for Revision |
|
2021-04-17 13:53 |
|
Revised |
|
2021-05-01 20:08 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2021-08-09 02:29 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2021-08-09 09:02 |
|
Articles in Press |
|
2021-08-09 09:02 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2021-08-12 02:03 |
|
Publish the Manuscript Online |
|
2021-08-18 08:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Artem Mashukov, Dmytro Shapochka, Oleksii Seleznov, Nazarii Kobyliak, Tetyana Falalyeyeva, Stanislav Kirkilevsky, Roman Yarema and Oksana Sulaieva |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Nazarii Kobyliak, PhD, Associate Professor, Department of Endocrinology, Bogomolets National Medical University, Pushkinska 22a str., Kyiv 01601, Ukraine. nazariikobyliak@gmail.com |
| Key Words |
Gastric carcinoma; Tumor immune microenvironment; Tumor infiltrating lymphocytes; Tumor associated macrophages |
| Core Tip |
In this study, we investigated the tumor-host interplay in gastric carcinoma (GC) through the tumor immune cycle concept. Histologically different GCs vary in immunogenicity and differ in tumor-infiltrating lymphocyte and macrophage densities. Intestinal GC demonstrated predominantly inflamed tumor immune microenvironment and frequent programmed death-ligand 1 expression. In contrast, more aggressive diffuse and mucinous GCs possessed low immunogenicity with a lack of cancer antigen recognition and trafficking. These data help to clarify the links between tumor histogenesis and immunogenicity, offering a better understanding of GC biology and the ability to provide more tailored patient management. |
| Publish Date |
2021-08-18 08:08 |
| Citation |
Mashukov A, Shapochka D, Seleznov O, Kobyliak N, Falalyeyeva T, Kirkilevsky S, Yarema R, Sulaieva O. Histological differentiation impacts the tumor immune microenvironment in gastric carcinoma: Relation to the immune cycle. World J Gastroenterol 2021; 27(31): 5259-5271 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i31/5259.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i31.5259 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
