Publication Name	World Journal of Gastroenterology
Manuscript ID	6534
Country	United States

Received	2013-10-23 10:38
Peer-Review Started	2013-10-24 08:58
To Make the First Decision	2013-12-16 17:54
Return for Revision	2013-12-18 10:52
Revised	2014-01-07 18:58
Second Decision	2014-04-03 10:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-03 11:27
Articles in Press	2014-05-23 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-04 17:11
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Ahmed Tawfik, Paul K Flanagan and Barry J Campbell
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Higher Education and Scientific Research/Cultural Attache - London Libyan Embassy UM873-611-23962 National Institute for Health Research (NIHR) Biomedical Research Fellowship BRF-2011-025 Shire Innovation Fund for Specialist Registrars Crohn’s amd Colitis United Kingdom M-08-1/M-13-2 Liverpool NIHR-Biomedical Research Centre for Microbial Diseases (01CD1) European Science Foundation, in the framework of the Research Networking Programme, The European Network for Gastrointestinal Health Research
Corresponding Author	Dr. Barry J Campbell, Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Nuffield Building, Crown Street, Liverpool, L69 3GE, United Kingdom. bjcampbl@liv.ac.uk
Key Words	Crohn’s disease; Inflammatory bowel disease; Escherichia coli; Intra-macrophage survival and replication; Phagolysosome; Autophagy
Core Tip	There is significant evidence implicating adherent, invasive mucosa-associated Escherichia coli (AIEC) in the pathogenesis of Crohn’s disease. AIEC translocate M-cells of Peyer’s patches and lymphoid follicles of the colon, and then to survive and replicate within underlying mucosal macrophages. How Crohn’s AIEC resist killing and adapt to the environment within the phagolysosme to survive and grow within macrophages is still poorly understood. Here we review the current understanding of the role of AIEC in Crohn’s pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular AIEC.
Publish Date	2014-07-21 17:17
Citation	Tawfik A, Flanagan PK, Campbell BJ. Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2014; 20(27): 8751-8763
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8751.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8751

Full Article (PDF)	WJG-20-8751.pdf
Full Article (Word)	WJG-20-8751.doc
Manuscript File	6534-Review.docx
Answering Reviewers	6534-Answering reviewers.pdf
Copyright License Agreement	6534-Copyright assignment.pdf
Peer-review Report	6534-Peer review(s).pdf
Scientific Editor Work List	6534-Scientific editor work list.doc