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Articles Published Processes
10/22/2021 1:53:28 PM | Browse: 416 | Download: 873
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Received |
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2021-03-04 21:56 |
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Peer-Review Started |
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2021-03-04 22:04 |
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To Make the First Decision |
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Return for Revision |
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2021-05-02 23:42 |
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Revised |
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2021-05-14 22:40 |
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Second Decision |
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2021-09-09 03:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-09-10 09:30 |
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Articles in Press |
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2021-09-10 09:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-20 06:04 |
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Publish the Manuscript Online |
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2021-10-22 13:53 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Natalia Echeverría, Victoria Comas, Fabián Aldunate, Paula Perbolianachis, Pilar Moreno and Juan Cristina |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Programa de Desarrollo de las Ciencias Básicas (PEDECIBA) |
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| Comisión Académica de Posgrados, Universidad de la República Uruguay (UdelaR) |
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| Comisión Sectorial de Investigación Científica (CSIC, I+D Project ID288) |
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| Corresponding Author |
Juan Cristina, PhD, Full Professor, Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Mataojo 2055, Montevideo 11400, Uruguay. cristina@cin.edu.uy |
| Key Words |
Hepatitis C virus; Vaccine candidates; Nucleic acid-based vaccines; Recombinant vector-based vaccines; Challenges |
| Core Tip |
Hepatitis C virus (HCV) remains a global health burden despite the successful introduction of direct-acting antiviral therapies. In order to achieve global control of HCV epidemic a vaccine is necessary. Its development has faced many hurdles, reason why it is still elusive. Herein, we describe all the challenges during HCV vaccine research, focusing on HCV immunology and emphasizing on current vaccine candidates, particularly nucleic acid-based as well as recombinant vector-based vaccines. We also highlight the impact of severe acute respiratory syndrome coronavirus-2 vaccine race on the renewed interest on HCV vaccine production. Finally, we present ideas on live-attenuated vaccine approaches against HCV. |
| Publish Date |
2021-10-22 13:53 |
| Citation |
Echeverría N, Comas V, Aldunate F, Perbolianachis P, Moreno P, Cristina J. In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet? World J Hepatol 2021; 13(10): 1234-1268 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i10/1234.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i10.1234 |
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