Publication Name	World Journal of Hepatology
Manuscript ID	65389
Country	Thailand

Received	2021-03-05 16:34
Peer-Review Started	2021-03-05 16:39
To Make the First Decision
Return for Revision	2021-03-29 15:54
Revised	2021-04-06 16:00
Second Decision	2021-11-11 03:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-15 03:10
Articles in Press	2021-11-15 03:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-21 04:04
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Dengue hemorrhagic fever and the liver
Manuscript Source	Invited Manuscript
All Author List	Wattana Leowattana and Tawithep Leowattana
ORCID	Author(s) ORCID Number Wattana Leowattana http://orcid.org/0000-0003-4257-2480 Tawithep Leowattana http://orcid.org/0000-0003-2316-3585
Funding Agency and Grant Number
Corresponding Author	Wattana Leowattana, BSc, MD, MSc, PhD, Associate Professor, Senior Researcher, Staff Physician, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajavithi Road, Rachatawee, Bangkok 10400, Bangkok, Thailand. wattana.leo@mahidol.ac.th
Key Words	Dengue hemorrhagic fever; Dengue viral infection; Liver involvement; Liver injury; Acute liver failure; Hepatocyte apoptosis; Cytokine storm; Severe dengue disease
Core Tip	The liver is the most common organ involvement in dengue hemorrhagic fever (DHF) patients with ranges from mild subclinical biochemical changes to severe liver disease as an acute liver failure (ALF). However, the low incidence of ALF in DHF with liver injury is associated with a high fatality rate. The hepatocyte injury is caused by direct viral cytopathic, immune-mediated, and poor hepatic perfusion. Early detection of severe hepatocellular injury development may reduce the morbidity and mortality in DHF patients with liver involvement.
Publish Date	2021-12-27 05:24
Citation	Leowattana W, Leowattana T. Dengue hemorrhagic fever and the liver. World J Hepatol 2021; 13(12): 1968-1976
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/1968.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.1968

Full Article (PDF)	WJH-13-1968.pdf
Full Article (Word)	WJH-13-1968.docx
Manuscript File	65389_Auto_Edited.docx
Answering Reviewers	65389-Answering reviewers.pdf
Audio Core Tip	65389-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65389-Conflict-of-interest statement.pdf
Copyright License Agreement	65389-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65389-Language certificate.pdf
Peer-review Report	65389-Peer-review(s).pdf
Scientific Misconduct Check	65389-Bing-Wu YXJ-2.jpg
Scientific Misconduct Check	65389-Bing-Ma YJ-1.jpg
Scientific Editor Work List	65389-Scientific editor work list.pdf
CrossCheck Report	65389-CrossCheck report.pdf