Publication Name	World Journal of Hepatology
Manuscript ID	65574
Country	India

Received	2021-03-10 09:24
Peer-Review Started	2021-03-10 09:31
To Make the First Decision
Return for Revision	2021-05-02 05:00
Revised	2021-05-12 09:49
Second Decision	2021-09-08 03:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-08 18:59
Articles in Press	2021-09-08 18:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-10-02 17:10
Typeset the Manuscript	2021-11-19 00:45
Publish the Manuscript Online	2021-11-24 09:54

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities
Manuscript Source	Invited Manuscript
All Author List	Abhiram Natu, Anjali Singh and Sanjay Gupta
ORCID	Author(s) ORCID Number Abhiram Natu http://orcid.org/0000-0002-6498-6134 Anjali Singh http://orcid.org/0000-0002-0558-5664 Sanjay Gupta http://orcid.org/0000-0002-1209-189X
Funding Agency and Grant Number
Corresponding Author	Sanjay Gupta, PhD, Senior Scientist, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Kharghar, Navi Mumbai 410210, Maharashtra, India. sgupta@actrec.gov.in
Key Words	Hepatocellular carcinoma; Diagnosis; Treatment; Epigenetics; Epi-drugs; Drug resistance
Core Tip	The review article briefs about limitations of diagnosis and treatment of hepatocellular carcinoma (HCC). Further, the article discusses the use of omics technology with clinical attributes for categorizing HCC patients so that personalized treatment can be designed to prolong survival. Finally, the potential of epi-drugs in targeting epigenetic changes in the disease and resistance has been put forth.
Publish Date	2021-11-24 09:54
Citation	Natu A, Singh A, Gupta S. Hepatocellular carcinoma: Understanding molecular mechanisms for defining potential clinical modalities. World J Hepatol 2021; 13(11): 1568-1583
URL	https://www.wjgnet.com/1948-5182/full/v13/i11/1568.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i11.1568

Full Article (PDF)	WJH-13-1568.pdf
Full Article (Word)	WJH-13-1568.docx
Manuscript File	65574_Auto_Edited-Webster J-Clear.docx
Answering Reviewers	65574-Answering reviewers.pdf
Audio Core Tip	65574-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65574-Conflict-of-interest statement.pdf
Copyright License Agreement	65574-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65574-Language certificate.pdf
Peer-review Report	65574-Peer-review(s).pdf
Scientific Misconduct Check	65574-Bing Liu M-1.png
Scientific Misconduct Check	65574-Bing Wu YXJ-2.jpg
Scientific Editor Work List	65574-Scientific editor work list.pdf
CrossCheck Report	65574-CrossCheck report.pdf