Publication Name	World Journal of Clinical Cases
Manuscript ID	65645
Country	China

Received	2021-03-12 06:57
Peer-Review Started	2021-03-12 07:00
To Make the First Decision
Return for Revision	2021-07-16 02:57
Revised	2021-07-26 15:45
Second Decision	2021-09-14 03:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-16 23:13
Articles in Press	2021-09-16 23:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-18 03:31
Publish the Manuscript Online	2021-10-21 08:44

ISSN	2307-8960 (online)
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Category	Orthopedics
Manuscript Type	Retrospective Study
Article Title	Preliminary establishment of a spinal stability scoring system for multiple myeloma
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Chen Yao, Xiang-Jun Shi, Zi-Yu Xu, Jie Tan, Yan-Zhe Wei, Lei Qi, Zi-Hao Zhou and Xin-Ru Du
ORCID	Author(s) ORCID Number Xing-Chen Yao http://orcid.org/0000-0002-1317-3782 Xiang-Jun Shi http://orcid.org/0000-0003-3647-1675 Zi-Yu Xu http://orcid.org/0000-0002-7551-8889 Jie Tan http://orcid.org/0000-0001-6682-633X Yan-Zhe Wei http://orcid.org/0000-0003-3755-4966 Lei Qi http://orcid.org/0000-0002-4833-366X Zi-Hao Zhou http://orcid.org/0000-0002-8401-3647 Xin-Ru Du http://orcid.org/0000-0002-9694-4377
Funding Agency and Grant Number
Corresponding Author	Xin-Ru Du, PhD, Professor, Department of Orthopedic, Beijing Chaoyang Hospital, Gongren Tiyuguan Nanlu No. 8, Beijing 100020, China. duxinru@163.com
Key Words	Multiple myeloma; Stability assessment; Spine; Spinal instability neoplastic score; Patient-specific modeling
Core Tip	Multiple myeloma (MM) is an incurable malignant plasma cell disorder that represents the most common primary malignant bone tumor. According to the 2010 Spine Oncology Study Group, spinal instability is defined as the loss of spinal integrity due to tumor growth, which is associated with motor-related pain and symptoms, progressive deformities, and/or impairments in neurological function under physiological loads. Many studies have validated this scoring system and applied it in clinical practice for diseases including primary spinal tumors, metastatic spinal tumors, and MM. However, MM is different from other primary and metastatic malignant tumors of the spine. Osteolytic destruction is the most common type of bone destruction in most MM patients; it commonly involves bone metastasis in multiple vertebral bodies, and is often accompanied by peripheral soft tissue masses and nerve compression symptoms. To some extent, Spinal Instability Neoplastic Score is not applicable to MM patients. Based on the disease characteristics of multiple myeloma, a simple and practical new method for evaluating spinal stability in individuals with multiple myeloma is proposed, and can be used for the clinical evaluation and intervention of multiple myeloma patients.
Publish Date	2021-10-21 08:44
Citation	Yao X, Shi X, Xu Z, Tan J, Wei Y, Qi L, Zhou Z, Du X. Preliminary establishment of a spinal stability scoring system for multiple myeloma. World J Clin Cases 2021; 9(30): 9023-9037
URL	https://www.wjgnet.com/2307-8960/full/v9/i30/9023.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i30.9023

Full Article (PDF)	WJCC-9-9023.pdf
Full Article (Word)	WJCC-9-9023.docx
Manuscript File	65645_Auto_Edited.docx
Answering Reviewers	65645-Answering reviewers.pdf
Audio Core Tip	65645-Audio core tip.m4a
Biostatistics Review Certificate	65645-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	65645-Conflict-of-interest statement.pdf
Copyright License Agreement	65645-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	65645-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	65645-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	65645-Language certificate.pdf
Peer-review Report	65645-Peer-review(s).pdf
Scientific Editor Work List	65645-Scientific editor work list.pdf