Publication Name	World Journal of Stem Cells
Manuscript ID	65761
Country	Australia

Received	2021-03-18 09:59
Peer-Review Started	2021-03-18 10:04
To Make the First Decision
Return for Revision	2021-06-16 04:04
Revised	2021-06-21 20:12
Second Decision	2021-09-13 02:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-17 00:21
Articles in Press	2021-09-17 00:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-18 06:56
Publish the Manuscript Online	2021-10-26 03:59

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Alternative RNA splicing in stem cells and cancer stem cells: Importance of transcript-based expression analysis
Manuscript Source	Invited Manuscript
All Author List	Esmaeil Ebrahimie, Samira Rahimirad, Mohammadreza Tahsili and Manijeh Mohammadi-Dehcheshmeh
ORCID	Author(s) ORCID Number Esmaeil Ebrahimie http://orcid.org/0000-0002-4431-2861 Samira Rahimirad http://orcid.org/0000-0002-1997-7327 Mohammadreza Tahsili http://orcid.org/0000-0002-8635-332X Manijeh Mohammadi-Dehcheshmeh http://orcid.org/0000-0002-8019-4081
Funding Agency and Grant Number
Corresponding Author	Esmaeil Ebrahimie, PhD, Associate Professor, School of Animal and Veterinary Sciences, The University of Adelaide, No. 1 Mudla Wirra Rd, Roseworthy Campus, Adelaide 5005, South Australia, Australia. esmaeil.ebrahimie@adelaide.edu.au
Key Words	Alternative splicing; Stem cell; Cancer stem cell; Transcriptome; Expression analysis
Core Tip	The alternative splicing machinery can produce various variants, associated with stemness characteristics of both stem cells (SCs) and cancer SCs. In this study, the role of spliced variants in SCs and stem-like cancer cells is reviewed. We highlight the importance of transcript-based expression concurrent with the gene and protein expression that leads to better understanding of self-renewal features of tumor cells.
Publish Date	2021-10-26 03:59
Citation	Ebrahimie E, Rahimirad S, Tahsili M, Mohammadi-Dehcheshmeh M. Alternative RNA splicing in stem cells and cancer stem cells: Importance of transcript-based expression analysis. World J Stem Cells 2021; 13(10): 1394-1416
URL	https://www.wjgnet.com/1948-0210/full/v13/i10/1394.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i10.1394

Full Article (PDF)	WJSC-13-1394.pdf
Full Article (Word)	WJSC-13-1394.docx
Manuscript File	65761_Auto_Edited.docx
Answering Reviewers	65761-Answering reviewers.pdf
Audio Core Tip	65761-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	65761-Conflict-of-interest statement.pdf
Copyright License Agreement	65761-Copyright license agreement.pdf
Peer-review Report	65761-Peer-review(s).pdf
Scientific Misconduct Check	65761-Bing-Chang KL-2.jpg
Scientific Editor Work List	65761-Scientific editor work list.pdf
CrossCheck Report	65761-CrossCheck report.pdf