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12/3/2021 7:34:23 AM | Browse: 971 | Download: 1879
Publication Name World Journal of Gastroenterology
Manuscript ID 65779
Country Türkiye
Received
2021-03-15 18:57
Peer-Review Started
2021-03-15 19:20
First Decision by Editorial Office Director
2021-06-03 22:53
Return for Revision
2021-06-03 22:53
Revised
2021-06-14 14:18
Publication Fee Transferred
Second Decision by Editor
2021-11-24 03:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2021-11-25 01:28
Articles in Press
2021-11-25 01:28
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-30 23:50
Publish the Manuscript Online
2021-12-03 07:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Orosomucoid in liver diseases
Manuscript Source Invited Manuscript
All Author List Gulsum Ozlem Elpek
ORCID
Author(s) ORCID Number
Gulsum Ozlem Elpek http://orcid.org/0000-0002-1237-5454
Funding Agency and Grant Number
Corresponding Author Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words Orosomucoid; Alpha-1-acid glycoprotein; Viral hepatitis; cirrhosis; Hepatocellular carcinoma; Downregulation
Core Tip Orosomucoid (ORM) has been suggested as a noninvasive marker in the diagnosis and follow-up of liver diseases. Currently, the results support the hypothesis that ORM can be used together with other markers to diagnose acute liver failure, monitor the development of cirrhosis, and detect early hepatocellular carcinoma (HCC). Although its role in carcinogenesis has not been entirely determined, the fact that decreased ORM2 expression is associated with carcinogenesis and poor prognosis warrants further study with the aim of better understanding the role of ORM in tumor behavior. The use of ORM expression to distinguish HCC from other neoplastic lesions and its role in differential diagnosis await investigation.
Publish Date 2021-12-03 07:34
Citation Elpek GO. Orosomucoid in liver diseases. World J Gastroenterol 2021; 27(45): 7739-7747
URL https://www.wjgnet.com/1007-9327/full/v27/i45/7739.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i45.7739
Full Article (PDF) WJG-27-7739.pdf
Full Article (Word) WJG-27-7739.docx