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Articles Published Processes
1/20/2022 10:47:59 AM | Browse: 427 | Download: 899
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Received |
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2021-03-16 15:10 |
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Peer-Review Started |
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2021-03-16 15:22 |
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To Make the First Decision |
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Return for Revision |
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2021-05-05 04:58 |
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Revised |
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2021-05-13 09:57 |
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Second Decision |
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2021-12-13 03:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-23 05:43 |
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Articles in Press |
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2021-12-23 05:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-12-09 02:19 |
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Typeset the Manuscript |
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2022-01-06 08:28 |
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Publish the Manuscript Online |
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2022-01-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chuan-Jing Dai, Yu-Ting Cao, Fang Huang and Yi-Gang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81803069 |
| Natural Science Foundation of Zhejiang Province |
LY18C070002 |
| the 521 Talent Project of Zhejiang Sci-Tech University |
2021437620, 2019337459 |
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| Corresponding Author |
Yi-Gang Wang, PhD, Associate Professor, Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 2 Street of Xiasha District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com |
| Key Words |
Cancer therapy; Drug resistance; Mothers against decapentaplegic homolog 4; Stemness; Transforming growth factor-β; Tumorigenesis |
| Core Tip |
Mothers against decapentaplegic homolog 4 (Smad4) is regarded as a tumor suppressor. Recent studies have shown that Smad4 plays a tumor-promoting role in specific types of cancer, rather than a tumor-suppressing role. Smad4 also correlates with the stem cells fate and drug resistance of cancer cells. Elucidating the specific role of Smad4 is of positive guiding significance for understanding the mechanism of tumorigenesis and cancer treatment. In this review, we focus on the multiple roles of Smad4 in tumorigenesis, stem cells, and drug resistance, and provide novel insights into the prospect of Smad4 in combination therapy. |
| Publish Date |
2022-01-20 10:47 |
| Citation |
Dai CJ, Cao YT, Huang F, Wang YG. Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy. World J Stem Cells 2022; 14(1): 41-53 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i1/41.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i1.41 |
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