Publication Name	World Journal of Hepatology
Manuscript ID	65871
Country	United States

Received	2021-03-17 03:19
Peer-Review Started	2021-03-17 03:52
To Make the First Decision
Return for Revision	2021-05-02 04:50
Revised	2021-07-05 23:53
Second Decision	2021-09-22 03:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-23 07:31
Articles in Press	2021-09-23 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-18 03:18
Publish the Manuscript Online	2021-11-24 09:54

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Newly discovered endocrine functions of the liver
Manuscript Source	Invited Manuscript
All Author List	Jane Rhyu and Run Yu
ORCID	Author(s) ORCID Number Jane Rhyu http://orcid.org/0000-0003-0407-4907 Run Yu http://orcid.org/0000-0003-2901-5102
Funding Agency and Grant Number
Corresponding Author	Run Yu, MD, PhD, Professor, Division of Endocrinology, Diabetes, and Metabolism, UCLA David Geffen School of Medicine, 200 Medical Plaza Driveway #530, Los Angeles, CA 90095, United States. runyu@mednet.ucla.edu
Key Words	Liver; Endocrine function; Hormone; Amino acids; Hepatokine; Fibroblast growth factor 21
Core Tip	The liver has many newly discovered endocrine functions, most of which are in regulating metabolism, underscoring the functioning of the liver as a major metabolic organ. Convincing evidence has shown that the liver regulates endocrine functions in mineral and fuel metabolism, especially in the metabolism of glucose and lipids via hepatokines and amino acids via negative feedback on pancreatic α cells. As research into the endocrine function of the liver is a rapidly evolving field, controversial findings often exist; caution needs to be taken when interpreting novel findings to avoid over-simplification of complex metabolic processes and premature allocation of research resources.
Publish Date	2021-11-24 09:54
Citation	Rhyu J, Yu R. Newly discovered endocrine functions of the liver. World J Hepatol 2021; 13(11): 1611-1628
URL	https://www.wjgnet.com/1948-5182/full/v13/i11/1611.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i11.1611

Full Article (PDF)	WJH-13-1611.pdf
Full Article (Word)	WJH-13-1611.docx
Manuscript File	65871_Auto_Edited.docx
Answering Reviewers	65871-Answering reviewers.pdf
Audio Core Tip	65871-Audio core tip
Conflict-of-Interest Disclosure Form	65871-Conflict-of-interest statement.pdf
Copyright License Agreement	65871-Copyright license agreement.pdf
Supplementary Material	65871-Copyright permission.eml
Peer-review Report	65871-Peer-review(s).pdf
Scientific Misconduct Check	65871-Bing-Liu M-1.png
Scientific Editor Work List	65871-Scientific editor work list.pdf
CrossCheck Report	65871-CrossCheck report.pdf