Publication Name	World Journal of Gastroenterology
Manuscript ID	6588
Country	Taiwan

Received	2013-10-24 18:06
Peer-Review Started	2013-10-25 18:55
To Make the First Decision	2013-12-16 17:53
Return for Revision	2013-12-18 10:16
Revised	2013-12-26 09:33
Second Decision	2014-02-27 11:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-27 11:27
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-26 19:02
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
Manuscript Source	Invited Manuscript
All Author List	Hsin-Chen Lee, Kuo-Hung Huang, Tien-Shun Yeh and Chin-Wen Chi
Funding Agency and Grant Number	Funding Agency Grant Number Center of Excellence for Cancer Research at Taipei Veterans General, the Ministry of Health and Welfare DOH102-TDC-111-007 Ministry of Education, Aim for the Top University Plan National Science Council, Taiwan NSC101-2320-B-010-068-MY3
Corresponding Author	Hsin-Chen Lee, Professor, Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Li-Nong St., Sec. 2, Taipei 112, Taiwan. hclee2@ym.edu.tw
Key Words	Gastric cancer; Somatic mitochondrial DNA mutations; Mitochondrial dysfunction
Core Tip	In this review, we summarize recent somatic mitochondrial DNA (mtDNA) alterations identified in gastric cancer, and the relationship between these alterations and the clinicopathological features of gastric cancer. We suggest that point mutations and mtDNA copy number decreases are the two most common mtDNA alterations that potentially result in mitochondrial dysfunction in gastric cancer. Mitochondrial dysfunction-generated reactive oxygen species may be involved in the malignant changes of gastric cancer. The search for strategies to prevent the mtDNA alterations and inhibit the mitochondrial retrograde signaling will benefit the development of novel treatments for gastric cancer and other malignancies.
Publish Date	2014-04-14 10:49
Citation	Lee HC, Huang KH, Yeh TS, Chi CW. Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression. World J Gastroenterol 2014; 20(14): 3950-3959
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3950.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3950

Full Article (PDF)	WJG-20-3950.pdf
Full Article (Word)	WJG-20-3950.doc
Manuscript File	6588-Review.docx
Answering Reviewers	6588-Answering reviewers.pdf
Copyright License Agreement	6588-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6588-Language certificate.pdf
Peer-review Report	6588-Peer review.pdf
Scientific Editor Work List	6588-Scientific editor work list.doc