Publication Name	World Journal of Gastroenterology
Manuscript ID	65904
Country	Argentina

Received	2021-03-17 16:15
Peer-Review Started	2021-03-17 16:31
To Make the First Decision
Return for Revision	2021-05-01 04:41
Revised	2021-05-06 17:30
Second Decision	2021-05-20 08:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-20 11:10
Articles in Press	2021-05-20 11:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-28 23:22
Typeset the Manuscript	2021-06-22 03:44
Publish the Manuscript Online	2021-06-25 09:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?
Manuscript Source	Invited Manuscript
All Author List	Federico Piñero and Leonardo Gomes da Fonseca
ORCID	Author(s) ORCID Number Federico Piñero http://orcid.org/0000-0002-9528-2279 Leonardo Gomes da Fonseca http://orcid.org/0000-0002-0216-3618
Funding Agency and Grant Number
Corresponding Author	Federico Piñero, MD, MSc, Academic Research, Doctor, Doctor, Hepatology and Liver Unit, Hospital Universitario Austral, School of Medicine, Austral University, Av. Presidente Perón 1500, Pilar, Buenos Aires B1629HJ, Argentina. fpinerof@cas.austral.edu.ar
Key Words	Eligibility; Systemic therapies; End-stage; Hepatocellular carcinoma
Core Tip	The strict criteria used in clinical trials in advanced hepatocellular carcinoma have led to a scarcity of available data in a considerable proportion of patients in the real-world practice. The daily challenge of treating these underrepresented subgroups can be overcome by future clinical trials addressing special situations, collaborative studies and real-world data.
Publish Date	2021-06-25 09:46
Citation	Piñero F, da Fonseca LG. Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups? World J Gastroenterol 2021; 27(24): 3429-3439
URL	https://www.wjgnet.com/1007-9327/full/v27/i24/3429.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i24.3429

Full Article (PDF)	WJG-27-3429.pdf
Full Article (Word)	WJG-27-3429.docx
Manuscript File	65904-Review-Filipodia CL.docx
Answering Reviewers	65904-Answering reviewers.pdf
Audio Core Tip	65904-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65904-Conflict-of-interest statement.pdf
Copyright License Agreement	65904-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65904-Language certificate.pdf
Peer-review Report	65904-Peer-review(s).pdf
Scientific Misconduct Check	65904-Bing-Liu M-1.png
Scientific Misconduct Check	65904-Scientific misconduct check.pdf
Scientific Editor Work List	65904-Scientific editor work list.pdf
CrossCheck Report	65904-CrossCheck report.pdf