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Articles Published Processes
11/10/2021 7:13:09 AM | Browse: 413 | Download: 673
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Received |
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2021-03-17 21:07 |
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Peer-Review Started |
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2021-03-17 21:11 |
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To Make the First Decision |
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Return for Revision |
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2021-05-01 04:28 |
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Revised |
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2021-05-08 18:08 |
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Second Decision |
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2021-10-19 07:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-10-20 00:32 |
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Articles in Press |
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2021-10-20 00:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-09 01:46 |
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Publish the Manuscript Online |
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2021-11-10 07:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Hemostasis testing in patients with liver dysfunction: Advantages and caveats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Guillaume Nguyen, Manon Lejeune, Benjamin Crichi and Corinne Frere |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Corinne Frere, MD, PhD, Assistant Professor, Department of Hematology, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, 47-83 Boulevard de l'Hôpital, Paris 75013, France. corinne.frere@aphp.fr |
| Key Words |
Hemostasis; Bleeding risk; Conventional tests; Thrombin generation; Viscoelastic tests; Hemostatic agents |
| Core Tip |
Patients with liver dysfunction have a “rebalanced hemostasis” which can easily be tipped toward either a hypo- or a hypercoagulable phenotype. Clinicians are often faced with the question whether patients with liver dysfunction undergoing invasive procedures or surgery and those having active bleeding require correction of hemostasis abnormalities. While conventional coagulation screening tests have numerous limitations and do not predict the risk of bleeding prior to high-risk procedures or during surgery, a growing body of evidence suggests that viscoelastic testing might be of significant clinical utility in this setting. The present review discusses the advantages and caveats of both conventional and global coagulation assays in patients with chronic liver disease and the current role of hemostatic agents to prevent and manage bleeding. |
| Publish Date |
2021-11-10 07:13 |
| Citation |
Nguyen G, Lejeune M, Crichi B, Frere C. Hemostasis testing in patients with liver dysfunction: Advantages and caveats. World J Gastroenterol 2021; 27(42): 7285-7298 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i42/7285.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i42.7285 |
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