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Articles Published Processes
12/24/2021 9:48:20 AM | Browse: 404 | Download: 705
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Received |
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2021-03-26 11:05 |
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Peer-Review Started |
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2021-03-26 11:09 |
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To Make the First Decision |
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Return for Revision |
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2021-10-16 07:26 |
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Revised |
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2021-10-28 20:47 |
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Second Decision |
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2021-12-20 03:27 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-22 23:32 |
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Articles in Press |
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2021-12-22 23:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-23 02:47 |
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Publish the Manuscript Online |
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2021-12-24 09:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Frontier |
| Article Title |
New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Blaž Trotovšek, Mihajlo Djokić, Maja Čemažar and Gregor Serša |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Slovenian Research Agency (ARRS) |
P3-0003 |
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| Corresponding Author |
Blaž Trotovšek, MD, PhD, Associate Professor, Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloska cesta 7, Ljubljana 1000, Slovenia. blaz.trotovsek@kclj.si |
| Key Words |
Electroporation; Electrochemotherapy; Gene therapy; Gene electrotransfer; Interleukin-12; Immune checkpoint inhibitors; Hepatocellular carcinoma |
| Core Tip |
Electrochemotherapy was found to be feasible, safe and highly effective for the treatment of hepatocellular carcinoma (HCC). A local immune response is induced through the destruction of tumor cells; therefore, the electrochemotherapy approach can be considered an in situ vaccination. Electrochemotherapy combined with immune checkpoint inhibitors had an interactive effect on melanoma tumors and HCC. Furthermore, electrochemotherapy can be combined with immunostimulation with cytokines. Electrochemotherapy involving the gene electrotransfer of a plasmid DNA coding for interleukin-12 (IL-12) has already been shown to have clinical value. The combination of electrochemotherapy and immunogene therapy with IL-12 via electroporation might be a feasible new treatment strategy for HCC that is also potentially applicable to other liver tumors. |
| Publish Date |
2021-12-24 09:48 |
| Citation |
Trotovšek B, Djokić M, Čemažar M, Serša G. New era of electrochemotherapy in treatment of liver tumors in conjunction with immunotherapies. World J Gastroenterol 2021; 27(48): 8216-8226 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i48/8216.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i48.8216 |
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