| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Minireviews |
| Article Title |
Angiotensin receptor blocker neprilysin inhibitors
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Daisuke Usuda, Toshihiro Higashikawa, Yuta Hotchi, Kenki Usami, Shintaro Shimozawa, Shungo Tokunaga, Ippei Osugi, Risa Katou, Sakurako Ito, Toshihiko Yoshizawa, Suguru Asako, Kentaro Mishima, Akihiko Kondo, Keiko Mizuno, Hiroki Takami, Takayuki Komatsu, Jiro Oba, Tomohisa Nomura and Manabu Sugita |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Daisuke Usuda, MD, MSc, PhD, Doctor, Doctor, Lecturer, Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima-ku 177-8521, Tokyo, Japan. d.usuda.qa@juntendo.ac.jp |
| Key Words |
Angiotensin receptor blocker and neprilysin inhibitor; Chronic heart failure; Renin-angiotensin-aldosterone-system; Sympathetic nervous system; Natriuretic peptide; Sacubitril/valsartan |
| Core Tip |
Heart failure (HF) is a multi-faceted clinical condition that affects up to 2% of the population in the developed world, and is linked to significant morbidity and mortality; it is therefore considered a major concern for public health. In 2014, a newly developed angiotensin receptor blocker and neprilysin inhibitor (angiotensin-receptor neprilysin inhibitor), namely sacubitril/valsartan (SAC/VAL), was introduced as a treatment for chronic HF (CHF), and it proved to have the efficacy, safety, and cost-effectiveness to improve quality of life and longevity in patients with heart failure with reduced ejection fraction and reduces hospital admission. In this review, we first summarize the current knowledge regarding HF, then provide an overview of the current knowledge on SAC/VAL for CHF, together with relevant clinical trials and future perspectives. |
| Publish Date |
2021-08-23 13:28 |
| Citation |
Usuda D, Higashikawa T, Hotchi Y, Usami K, Shimozawa S, Tokunaga S, Osugi I, Katou R, Ito S, Yoshizawa T, Asako S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, Sugita M. Angiotensin receptor blocker neprilysin inhibitors. World J Cardiol 2021; 13(8): 325-339 |
| URL |
https://www.wjgnet.com/1949-8462/full/v13/i8/325.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v13.i8.325 |
