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Articles Published Processes
2/17/2022 8:22:35 AM | Browse: 954 | Download: 2318
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Received |
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2021-03-18 08:24 |
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Peer-Review Started |
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2021-03-18 08:30 |
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First Decision by Editorial Office Director |
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2021-07-15 02:33 |
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Return for Revision |
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2021-07-15 02:33 |
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Revised |
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2021-08-14 05:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-01-10 05:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-01-10 22:59 |
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Articles in Press |
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2022-01-10 22:59 |
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Edit the Manuscript by Language Editor |
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2022-01-05 21:28 |
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Typeset the Manuscript |
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2022-02-09 08:07 |
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Publish the Manuscript Online |
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2022-02-17 08:22 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Observational Study |
| Article Title |
Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ana Paula Michelin, Michael H J Maes, Thitiporn Supasitthumrong, Chusak Limotai, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefânia Gastaldello Moreira, Buranee Kanchanatawan and Décio Sabbatini Barbosa |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| atchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University |
RA60/042 |
| atchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University |
RA61/050 |
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| Corresponding Author |
Michael H J Maes, MD, PhD, Professor, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Patumwan 1873, Bangkok 10330, Thailand. dr.michaelmaes@hotmail.com |
| Key Words |
Antioxidants; Oxidative stress; Neuroimmune; Major depression; Mood disorders; Affective disorders |
| Core Tip |
The severity of temporal lobe epilepsy (TLE) and mesial temporal sclerosis and their psychiatric comorbidities including depression, anxiety and psychosis are largely explained by lowered paraoxonase 1 (PON1) enzyme activities, which mediate the effects of the Q192R PON1 genotype on psychopathology and epilepsy severity. It is argued that PON1 status may play a key role in the pathophysiology of TLE, medial temporal sclerosis and its psychiatric comorbidities by increasing the risk of neuro-oxidative toxicity. It is concluded that PON1 enzyme activities are new drug targets to treat seizure frequency and psychiatric comorbidities in patients with TLE. |
| Publish Date |
2022-02-17 08:22 |
| Citation |
Michelin AP, Maes MHJ, Supasitthumrong T, Limotai C, Matsumoto AK, de Oliveira Semeão L, de Lima Pedrão JV, Moreira EG, Kanchanatawan B, Barbosa DS. Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis. World J Psychiatry 2022; 12(2): 308-322
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| URL |
https://www.wjgnet.com/2220-3206/full/v12/i2/308.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v12.i2.308 |
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