Publication Name	World Journal of Gastroenterology
Manuscript ID	66013
Country	Japan

Received	2021-03-26 08:19
Peer-Review Started	2021-03-26 08:24
To Make the First Decision
Return for Revision	2021-06-14 01:35
Revised	2021-06-25 03:59
Second Decision	2021-12-31 03:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-31 21:59
Articles in Press	2021-12-31 21:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-12-08 15:16
Typeset the Manuscript	2022-01-05 07:25
Publish the Manuscript Online	2022-01-11 08:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer
Manuscript Source	Invited Manuscript
All Author List	Kohji Yamada and Kiyotsugu Yoshida
ORCID	Author(s) ORCID Number Kohji Yamada http://orcid.org/0000-0001-9493-5269 Kiyotsugu Yoshida http://orcid.org/0000-0003-3108-7383
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science, KAKENHI Grant 19H03519 Japan Society for the Promotion of Science, KAKENHI Grant 16K18434 Japan Society for the Promotion of Science, KAKENHI Grant 18K19484 Japan Society for the Promotion of Science, KAKENHI Grant 17H03584 Japan Society for the Promotion of Science, KAKENHI Grant 18K15253 Japan Society for the Promotion of Science, KAKENHI Grant 20H03519 AMED under Grant A326TS The Jikei University Graduate Research Fund Science Research Promotion Fund
Corresponding Author	Kiyotsugu Yoshida, MD, PhD, Professor, Department of Biochemistry, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Tokyo 105-8461, Japan. kyoshida@jikei.ac.jp
Key Words	PKCδ; Liver cancer; Subcellular localization; Tumor suppression; Tumor progression
Core Tip	Protein kinase Cδ (PKCδ) plays multifunctional roles in various cancers, including liver cancer. PKCδ has been shown to exert pleiotropic functions through various stimuli responsiveness, post-translational modifications, and subcellular localization. Recently, we found that PKCδ is secreted extracellularly and resides on the cell surface of liver cancer cells, which contributes to tumorigenesis. In this review, we focus on the localization of PKCδ to discuss its characteristic localization patterns and functions in liver cancer, and outline the involvement of PKCδ localized intra- and extracellularly with distinct functions in the progression of liver cancer.
Publish Date	2022-01-11 08:34
Citation	Yamada K, Yoshida K. Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer. World J Gastroenterol 2022; 28(2): 188-198
URL	https://www.wjgnet.com/1007-9327/full/v28/i2/188.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i2.188

Full Article (PDF)	WJG-28-188.pdf
Full Article (Word)	WJG-28-188.docx
Manuscript File	66013_Auto_Edited.docx
Answering Reviewers	66013-Answering reviewers.pdf
Audio Core Tip	66013-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66013-Conflict-of-interest statement.pdf
Copyright License Agreement	66013-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	66013-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	66013-Language certificate.pdf
Peer-review Report	66013-Peer-review(s).pdf
Scientific Misconduct Check	66013-Bing-Yan JP-1.jpg
Scientific Editor Work List	66013-Scientific editor work list.pdf
CrossCheck Report	66013-CrossCheck report.pdf