Publication Name	World Journal of Clinical Cases
Manuscript ID	66014
Country	China

Received	2021-03-25 02:51
Peer-Review Started	2021-03-25 02:53
To Make the First Decision
Return for Revision	2021-06-16 11:16
Revised	2021-06-17 02:43
Second Decision	2021-08-19 03:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-19 07:27
Articles in Press	2021-08-19 07:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-04 05:23
Typeset the Manuscript	2021-10-09 03:22
Publish the Manuscript Online	2021-10-15 09:45

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Clinical and Translational Research
Article Title	Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Yan-Dong Miao, Zhi-Yong Kou, Jiang-Tao Wang and Deng-Hai Mi
ORCID	Author(s) ORCID Number Yan-Dong Miao http://orcid.org/0000-0002-1429-8915 Zhi-Yong Kou http://orcid.org/0000-0002-7965-9558 Jiang-Tao Wang http://orcid.org/0000-0002-1222-164X Deng-Hai Mi http://orcid.org/0000-0002-8643-4496
Funding Agency and Grant Number
Corresponding Author	Deng-Hai Mi, MD, Chief Doctor, Dean, Professor, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com
Key Words	Colon adenocarcinoma; Ferroptosis; Immune status; Prognosis; Overall survival
Core Tip	Colon adenocarcinoma is one of the most ordinary and fatal malignant tumors. Ferroptosis is a recently appeared type of programmed cell death process, which has the characteristics of iron-dependent lipid peroxide accumulation. In this work, we excavated five ferroptosis-related genes of colon adenocarcinoma from The Cancer Genome Atlas database. Then, we constructed a very accurate prognostic model based on the five genes (AKR1C1, AKR1C3, ALOX12, CRYAB, FDFT1). Our study also highlights the crucial roles of the risk score was an independent prognostic biomarker for CRC patients and we validated these genes in the outside data access (GSE39582).
Publish Date	2021-10-15 09:45
Citation	Miao YD, Kou ZY, Wang JT, Mi DH. Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma. World J Clin Cases 2021; 9(29): 8671-8693
URL	https://www.wjgnet.com/2307-8960/full/v9/i29/8671.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i29.8671

Full Article (PDF)	WJCC-9-8671.pdf
Full Article (Word)	WJCC-9-8671.docx
Manuscript File	66014-Review-Filipodia-CL.docx
Answering Reviewers	66014-Answering reviewers.pdf
Audio Core Tip	66014-Audio core tip.mp3
Biostatistics Review Certificate	66014-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	66014-Conflict-of-interest statement.pdf
Copyright License Agreement	66014-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	66014-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	66014-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	66014-Language certificate.pdf
Supplementary Material	66014-Supplementary material.pdf
Peer-review Report	66014-Peer-review(s).pdf
Scientific Misconduct Check	66014-Scientific misconduct check.pdf
Scientific Editor Work List	66014-Scientific editor work list.pdf
CrossCheck Report	66014-CrossCheck report.pdf