Publication Name	World Journal of Gastroenterology
Manuscript ID	6617
Country	Ireland

Received	2013-10-25 14:41
Peer-Review Started	2013-10-25 19:42
To Make the First Decision	2014-01-09 13:31
Return for Revision	2014-01-10 12:03
Revised
Second Decision	2014-05-29 20:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 20:54
Articles in Press	2014-05-29 21:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-10 09:03
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Maria M Buckley, Siobhain M O’Mahony and Dervla O’Malley
Funding Agency and Grant Number
Corresponding Author	Dervla O’Malley, BSc, DIS, PhD, Department of Physiology, Western Gateway Building, University College Cork, Western Rd, Cork, Ireland. d.omalley@ucc.ie
Key Words	Stress; Corticotropin-releasing factor; Pro-inflammatory cytokines; Enteric nervous system; Vagus
Core Tip	Irritable bowel syndrome (IBS) is a disorder characterised by symptoms such as diarrhoea and/or constipation, bloating and abdominal pain. However the underlying pathophysiology of this common disorder remains unclear. Nonetheless, a number of mechanisms have been proposed to contribute to the initiation, exacerbation and persistence of symptoms. Alterations in brain-gut communication, stress, previous infections, abnormal microbiota, altered cytokine profiles and increased intestinal permeability have all been proposed as contributors to IBS and indeed, we propose that complex interactions between neural, endocrine and immune factors underlie the heterogeneity of symptoms that is characteristic of IBS.
Publish Date	2014-07-21 17:17
Citation	Buckley MM, O’Mahony SM, O’Malley D. Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome. World J Gastroenterol 2014; 20(27): 8846-8858
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/8846.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.8846

Full Article (PDF)	WJG-20-8846.pdf
Full Article (Word)	WJG-20-8846.doc
Manuscript File	6617-Review.docx
Answering Reviewers	6617-Answering reviewers.pdf
Copyright License Agreement	6617-Copyright assignment.pdf
Peer-review Report	6617-Peer review(s).pdf
Scientific Misconduct Check	6617-CrossCheck.jpg
Scientific Editor Work List	6617-Scientific editor work list.pdf