Publication Name	World Journal of Stem Cells
Manuscript ID	66241
Country	Italy

Received	2021-03-26 14:33
Peer-Review Started	2021-03-26 14:36
To Make the First Decision
Return for Revision	2021-05-12 02:28
Revised	2021-05-26 16:41
Second Decision	2021-10-29 09:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-10-31 18:22
Articles in Press	2021-10-31 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-18 06:25
Publish the Manuscript Online	2021-11-25 08:31

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Why stem/progenitor cells lose their regenerative potential
Manuscript Source	Invited Manuscript
All Author List	Angela Picerno, Alessandra Stasi, Rossana Franzin, Claudia Curci, Ighli di Bari, Loreto Gesualdo and Fabio Sallustio
ORCID	Author(s) ORCID Number Angela Picerno http://orcid.org/0000-0001-5805-4341 Alessandra Stasi http://orcid.org/0000-0003-3652-3623 Rossana Franzin http://orcid.org/0000-0001-7907-7614 Claudia Curci http://orcid.org/0000-0003-2055-7837 Ighli di Bari http://orcid.org/0000-0003-4973-3523 Loreto Gesualdo http://orcid.org/0000-0002-4861-0911 Fabio Sallustio http://orcid.org/0000-0002-5132-6532
Funding Agency and Grant Number
Corresponding Author	Fabio Sallustio, PhD, Assistant Professor, Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, 11, Bari 70124 , Italy. fabio.sallustio@uniba.it
Key Words	Stem cells; Aging; Self-renewal; Rejuvenation; Aging-associated disorders; Epigenetic changes; Aging environment
Core Tip	Aging influences the ability of stem cell renewal, inducing a gradual functional decline of adult tissue-specific stem cells in maintaining homeostasis of the tissue and playing a role in the pathophysiology of various aging-associated disorders. Stem cell rejuvenation strategies may reverse this aging phenotype.
Publish Date	2021-11-25 08:31
Citation	Picerno A, Stasi A, Franzin R, Curci C, di Bari I, Gesualdo L, Sallustio F. Why stem/progenitor cells lose their regenerative potential. World J Stem Cells 2021; 13(11): 1714-1732
URL	https://www.wjgnet.com/1948-0210/full/v13/i11/1714.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i11.1714

Full Article (PDF)	WJSC-13-1714.pdf
Full Article (Word)	WJSC-13-1714.docx
Manuscript File	66241_Auto_Edited.docx
Answering Reviewers	66241-Answering reviewers.pdf
Audio Core Tip	66241-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66241-Conflict-of-interest statement.pdf
Copyright License Agreement	66241-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	66241-Language certificate.pdf
Peer-review Report	66241-Peer-review(s).pdf
Scientific Editor Work List	66241-Scientific editor work list.pdf
CrossCheck Report	66241-CrossCheck report.pdf