Publication Name	World Journal of Gastroenterology
Manuscript ID	6637
Country	Japan

Received	2013-10-26 09:40
Peer-Review Started	2013-10-26 12:57
First Decision by Editorial Office Director
Return for Revision	2013-12-04 16:37
Revised	2014-03-07 20:48
Publication Fee Transferred
Second Decision by Editor	2014-05-05 08:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-05 09:48
Articles in Press	2014-05-23 10:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-26 14:33
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD
Manuscript Source	Invited Manuscript
All Author List	Ken-ichi Mukaisho, Tadashi Hagiwara, Takahisa Nakayama, Takanori Hattori and Hiroyuki Sugihara
Funding Agency and Grant Number
Corresponding Author	Ken-ichi Mukaisho, Associate Professor, Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga University of Medical Science, Seta-tsukinowa-cho, Otsu, Shiga 520-2192, Japan. mukaisho@belle.shiga-med.ac.jp
Key Words	Helicobacter pylori; Proton pump inhibitor; Corpus-predominant gastritis; Bile acids; Gastroesophageal reflux disease; Chemotactic gradient
Core Tip	It has been widely accepted that the long-term use of proton pump inhibitors (PPIs) exacerbates corpus atrophic gastritis in patients with Helicobacter pylori (H. pylori) infection. Recently, we successfully demonstrated that long-term PPI administration promotes corpus atrophic gastritis in Mongolian gerbils, which are excellent models of H. pylori-related gastritis and adenocarcinoma. Here, we suggest a potential mechanism for corpus-predominant gastritis after PPI therapy in H. pylori-positive patients with gastroesophageal reflux disease that includes interactions between bile acids, pH, and H. pylori.
Publish Date	2014-09-18 19:50
Citation	Mukaisho K, Hagiwara T, Nakayama T, Hattori T, Sugihara H. Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD. World J Gastroenterol 2014; 20(34): 11962-11965
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/11962.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.11962

Full Article (PDF)	WJG-20-11962.pdf
Full Article (Word)	WJG-20-11962.doc
Manuscript File	6637-Review.docx
Answering Reviewers	6637-Answering reviewers.pdf
Copyright License Agreement	6637-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6637-Language certificate.pdf
Peer-review Report	6637-Peer review(s).pdf
Scientific Editor Work List	6637-Scientific editor work list.pdf