| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Milena Stevanovic, Natasa Kovacevic-Grujicic, Marija Mojsin, Milena Milivojevic and Danijela Drakulic |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Science and Technological Development of the Republic of Serbia |
451-03-9/2021-14/200042 |
|
| Corresponding Author |
Milena Stevanovic, PhD, Academic Fellow, Full Professor, Senior Research Fellow, Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade 152, Belgrade 11042, Serbia. milenastevanovic@imgge.bg.ac.rs |
| Key Words |
Glioblastoma; SOX transcription factors; Glioma stem cells; Stemness; Differentiation |
| Core Tip |
Despite the remarkable progress that has been made in understanding the cellular and molecular biology of gliomas, current therapeutic strategies have not yet provided a significant benefit to patients or a cure. This review highlights the key functions of SOX transcriptional factors (TFs) in glioblastoma (GBM) and glioma stem cells (GSCs). SOX TFs influence stemness, self-renewal, proliferation, differentiation, viability, migration, invasion, apoptosis, therapy resistance, sphere-forming capacity and tumorigenicity. We emphasized that fine-tuning of the SOX expression level is required to control the balance between the stemness and differentiation of GSCs, making SOX TFs promising therapeutic targets for combatting GBM. |
| Publish Date |
2021-10-26 03:59 |
| Citation |
Stevanovic M, Kovacevic-Grujicic N, Mojsin M, Milivojevic M, Drakulic D. SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation. World J Stem Cells 2021; 13(10): 1417-1445 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i10/1417.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i10.1417 |
