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Articles Published Processes
1/22/2022 6:08:15 AM | Browse: 705 | Download: 1849
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Received |
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2021-03-27 01:05 |
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Peer-Review Started |
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2021-03-27 01:09 |
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First Decision by Editorial Office Director |
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2021-07-27 06:23 |
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Return for Revision |
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2021-07-27 06:23 |
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Revised |
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2021-08-06 08:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-12-16 03:49 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-12-23 06:24 |
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Articles in Press |
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2021-12-23 06:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-19 17:20 |
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Publish the Manuscript Online |
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2022-01-22 06:08 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Current understanding of the role of tyrosine kinase 2 signaling in immune responses
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ryuta Muromoto, Kenji Oritani and Tadashi Matsuda |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology of Japan |
19H03364 |
| Grant-in-Aid for scientific research from Ministry of Education, Culture, Sports, Science and Technology of Japan |
20K07010 |
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| Corresponding Author |
Tadashi Matsuda, PhD, Professor, Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita12 Nishi 6, Sapporo 0600812, Japan. tmatsuda@pharm.hokudai.ac.jp |
| Key Words |
Tyrosine kinase 2; Cytokines; Signal transduction; Immune system; Inflammation |
| Core Tip |
Studies on murine tyrosine kinase 2 (Tyk2)-deficient models were reviewed to examine the role of Tyk2 dysregulation in human diseases. Tyk2-deficient mice exhibit reduced responses in several interleukin-12 (IL-12)/Th1- and IL-23/Th17-mediated models of diseases, including rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, psoriasis, sarcoidosis, and delayed-type hypersensitivity. These findings demonstrate a broad contribution of Tyk2 to immune responses. Tyk2 represents a candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes. |
| Publish Date |
2022-01-22 06:08 |
| Citation |
Muromoto R, Oritani K, Matsuda T. Current understanding of the role of tyrosine kinase 2 signaling in immune responses. World J Biol Chem 2022; 13(1): 1-14 |
| URL |
https://www.wjgnet.com/1949-8454/full/v13/i1/1.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v13.i1.1 |
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