Publication Name	World Journal of Gastroenterology
Manuscript ID	6643
Country	Spain

Received	2013-10-26 11:34
Peer-Review Started	2013-10-27 11:42
To Make the First Decision	2013-12-16 17:50
Return for Revision	2013-12-17 16:27
Revised	2014-01-24 21:58
Second Decision	2014-03-10 15:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-10 17:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-31 15:27
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Proteomics for discovery of candidate colorectal cancer biomarkers
Manuscript Source	Invited Manuscript
All Author List	Paula Álvarez-Chaver, Olalla Otero-Estévez, María Páez de la Cadena, Francisco J Rodríguez-Berrocal and Vicenta S Martínez-Zorzano
Funding Agency and Grant Number	Funding Agency Grant Number Xunta de Galicia 10PXIB310215PR REGICC CN 2012/217 Fundación Científica de la Asociación Española contra el Cáncer GCB13131592CAST Fondo de Investigaciones Sanitarias PI12/00117 FEDER
Corresponding Author	Vicenta S Martínez-Zorzano, PhD, Área de Bioquímica y Biología Molecular, Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, Campus As Lagoas-Marcosende, 36310 Vigo (Pontevedra), Spain. vzorzano@uvigo.es
Key Words	Colorectal cancer; Serum; Tissue; Proteins; Biomarkers; Proteomics; Protein identification; Mass spectrometry
Core Tip	Proteomics is an important tool for the identification of candidate cancer biomarkers since it allows the simultaneous analysis of multiple differentially expressed proteins in a single study. This review provides an overview of recent reports focused on the different proteomic tools used for the discovery of candidate protein markers for colorectal cancer (CRC), such as two-dimensional electrophoresis methods, quantitative mass spectrometry-based techniques or protein microarrays. We also emphasize the use of different samples including cell lines, murine models, clinical samples as tissue, serum or faeces, for CRC biomarker discovery, discussing their advantages and disadvantages, and finally summarize the candidate CRC markers most frequently identified.
Publish Date	2014-04-14 10:49
Citation	álvarez-Chaver P, Otero-Estévez O, Páez de la Cadena M, Rodríguez-Berrocal FJ, Martínez-Zorzano VS. Proteomics for discovery of candidate colorectal cancer biomarkers. World J Gastroenterol 2014; 20(14): 3804-3824
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3804.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3804

Full Article (PDF)	WJG-20-3804.pdf
Full Article (Word)	WJG-20-3804.doc
Manuscript File	6643-Review.doc
Answering Reviewers	6643-Answering reviewers.pdf
Copyright License Agreement	6643-Copyright assignment.pdf
Peer-review Report	6643-Peer review(s).pdf
Scientific Editor Work List	6643-Scientific editor work list.doc