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Articles Published Processes
9/18/2021 9:35:02 AM | Browse: 483 | Download: 862
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Received |
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2021-03-28 19:51 |
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Peer-Review Started |
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2021-03-28 19:54 |
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To Make the First Decision |
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Return for Revision |
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2021-05-12 02:19 |
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Revised |
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2021-05-22 03:48 |
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Second Decision |
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2021-08-18 03:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-18 08:37 |
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Articles in Press |
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2021-08-18 08:37 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-09-17 03:13 |
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Publish the Manuscript Online |
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2021-09-18 09:35 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe and Quan-Jun Cui |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Quan-Jun Cui, MD, Attending Doctor, Professor, Surgeon, Department of Orthopaedic Surgery, University of Virginia School of Medicine, 400 Ray C. Hunt Drive, Suite 330, Charlottesville, VA 22908, United States. qc4q@virginia.edu |
| Key Words |
Mesenchymal stem cells; Adipose-derived stem cells; Endogenous stem cells; Skeletal stem cells; Bone regeneration |
| Core Tip |
This review systematically examined current progress and future projections of Adipose-derived Stem Cells (ADSCs) use in bone regeneration. Introduction covered the regulatory aspects of stem cell therapy and scientific concerns regarding stem cell use including ADSCs. We then analyze clinical and pre-clinical studies using ADSCs for the treatment of bone defects. We also evaluate the current understanding of ADSC’s surface receptors and therapeutic subpopulations. Overall, we conclude that while mixed outcomes have been reported, a more rigorous definition of ADSCs, selection of osteogenic subpopulations, and understanding of signaling pathways will unleash ADSCs as a powerful tool in bone regeneration. |
| Publish Date |
2021-09-18 09:35 |
| Citation |
Le Q, Madhu V, Hart JM, Farber CR, Zunder ER, Dighe AS, Cui QJ. Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection. World J Stem Cells 2021; 13(9): 1248-1277 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i9/1248.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i9.1248 |
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