Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	66486
Country	United Kingdom

Received	2021-03-29 04:41
Peer-Review Started	2021-03-29 04:48
To Make the First Decision
Return for Revision	2021-06-23 23:33
Revised	2021-07-05 20:21
Second Decision	2021-08-23 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-23 08:20
Articles in Press	2021-08-23 08:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-08 16:19
Publish the Manuscript Online	2021-10-13 12:57

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Review
Article Title	Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis
Manuscript Source	Invited Manuscript
All Author List	Francesca Saffioti and Vasileios K Mavroeidis
ORCID	Author(s) ORCID Number Francesca Saffioti http://orcid.org/0000-0001-7635-9931 Vasileios K Mavroeidis http://orcid.org/0000-0002-8188-3575
Funding Agency and Grant Number
Corresponding Author	Vasileios K Mavroeidis, FICS, FRSC, MD, MSc, Surgeon, Department of Surgery, The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London SW3 6JJ, United Kingdom. vasileios.mavroeidis@nhs.net
Key Words	Cholangiocarcinoma; Primary sclerosing cholangitis; Liver resection; Liver transplantation; Neoadjuvant therapy; Adjuvant therapy
Core Tip	Cholangiocarcinoma (CCA) in primary sclerosing cholangitis (PSC) has become the leading cause of death. Major hepatic resection is commonly not possible in PSC patients to treat CCA, but overwhelming progress with excellent results in the last two decades has established an increasing role of protocolised combination of neoadjuvant chemoradiation and orthotopic liver transplantation. We review in detail, the incidence, as well as aspects of treatment and outcomes according to the different anatomical locations of CCA in PSC, through the viewpoint of historical evolution of treatment paradigms.
Publish Date	2021-10-13 12:57
Citation	Saffioti F, Mavroeidis VK. Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis. World J Gastrointest Oncol 2021; 13(10): 1336-1366
URL	https://www.wjgnet.com/1948-5204/full/v13/i10/1336.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i10.1336

Full Article (PDF)	WJGO-13-1336.pdf
Full Article (Word)	WJGO-13-1336.docx
Manuscript File	66486_Auto_Edited-JLW (3).docx
Answering Reviewers	66486-Answering reviewers.pdf
Audio Core Tip	66486-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66486-Conflict-of-interest statement.pdf
Copyright License Agreement	66486-Copyright license agreement.pdf
Peer-review Report	66486-Peer-review(s).pdf
Scientific Misconduct Check	66486-Bing-Wang LL-2.png
Scientific Misconduct Check	66486-Scientific misconduct check.pdf
Scientific Editor Work List	66486-Scientific editor work list.pdf
CrossCheck Report	66486-CrossCheck report.pdf