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Articles Published Processes
10/20/2021 7:18:39 AM | Browse: 461 | Download: 872
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Received |
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2021-03-29 12:45 |
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Peer-Review Started |
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2021-03-29 13:00 |
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To Make the First Decision |
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Return for Revision |
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2021-06-14 01:05 |
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Revised |
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2021-06-28 09:55 |
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Second Decision |
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2021-09-17 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-19 08:48 |
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Articles in Press |
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2021-09-19 08:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-18 05:27 |
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Publish the Manuscript Online |
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2021-10-20 07:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis – with impact on gastrointestinal tract
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Izabela Berdowska and Malgorzata Matusiewicz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Malgorzata Matusiewicz, PhD, Senior Lecturer, Department of Biochemistry and Immunochemistry, Wroclaw Medical University, Chalubinskiego 10, Wroclaw 50-368, Lower Silesia, Poland. malgorzata.matusiewicz@umed.wroc.pl |
| Key Words |
COVID-19; SARS-CoV-2; Angiotensin converting enzyme 2; Transmembrane peptidase/serine subfamily member 2/4; Cathepsin L; Gastrointestinal tract |
| Core Tip |
Gastrointestinal tract (GIT) is believed to participate in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) dissemination. The current research shows the abundance and co-localization of angiotensin converting enzyme 2 (ACE2) and transmembrane peptidase/serine subfamily member 2 receptors in the lower GIT. Furthermore, about half of COVID-19 patients present with GIT symptoms, such as diarrhea, and exhibit viral-shedding in feces. Additionally, in vitro studies have demonstrated the virions capability of infection and replication in the human epithelial cells lining GIT. This paper reviews the possible routes of the virus infection with respect to the host-enzymatic systems responsible for the proteolytic priming of SARS-CoV-2. |
| Publish Date |
2021-10-20 07:18 |
| Citation |
Berdowska I, Matusiewicz M. Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis – with impact on gastrointestinal tract. World J Gastroenterol 2021; 27(39): 6590-6600 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i39/6590.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i39.6590 |
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