| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jennifer Raisch, Emmanuel Buc, Mathilde Bonnet, Pierre Sauvanet, Emilie Vazeille, Amélie de Vallée, Pierre Déchelotte, Claude Darcha, Denis Pezet, Richard Bonnet, Marie-Agnès Bringer and Arlette Darfeuille-Michaud |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministère de l’Enseignement supérieur et de la Recherche, Inserm and Université d’Auvergne |
UMR1071 |
| INRA |
USC-2018 |
| Association F. Aupetit (AFA) and Ligue contre le cancer |
|
|
| Corresponding Author |
Marie-Agnès Bringer, PhD, Clermont Université, UMR1071 Inserm/Université d’Auvergne and INRA USC2018, 63000 Clermont-Ferrand, France. m-agnes.bringer@udamail.fr |
| Key Words |
B2 Escherichia coli; Carcinoembryonic antigen-related cell adhesion molecule 6; Cell proliferation; Colon cancer; Polyketide synthase genomic island |
| Core Tip |
Tumors and mucosa of patients with colon cancer are abnormally colonized by Escherichia coli (E. coli) belonging to B2 phylogroup. The aim of the present study was to provide further insight into the characterization of colon cancer-associated E. coli. Despite their poor ability to adhere to and to invade intestinal epithelial cells in vitro, we showed that colon cancer-associated E. coli induce carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression, a receptor involved in adhesion of pathogenic E. coli. These bacteria were also able to persist and promote low grade inflammation and cell proliferation, in a chronic infection model of CEACAM6 expressing mice, highlighting their oncogenic potential. |
| Publish Date |
2014-06-06 16:55 |
| Citation |
Raisch J, Buc E, Bonnet M, Sauvanet P, Vazeille E, de Vallée A, Déchelotte P, Darcha C, Pezet D, Bonnet R, Bringer MA, Darfeuille-Michaud A. Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation. World J Gastroenterol 2014; 20(21): 6560-6572 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i21/6560.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i21.6560 |
