Publication Name	World Journal of Hepatology
Manuscript ID	6653
Country	Thailand

Received	2013-10-26 12:14
Peer-Review Started	2013-10-27 12:16
To Make the First Decision	2013-12-13 13:23
Return for Revision	2013-12-13 15:19
Revised	2014-01-09 20:10
Second Decision	2014-04-03 10:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 10:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-08 20:32
Publish the Manuscript Online	2014-05-20 15:05

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions
Manuscript Source	Invited Manuscript
All Author List	Kangsadarn Bennukul, Sucha Numkliang and Vijittra Leardkamolkarn
Funding Agency and Grant Number	Funding Agency Grant Number Center of Excellence on Environmental Health and Toxicology, Science and Technology Postgraduate Education and Research Development Office, Thailand Ministry of Education
Corresponding Author	Vijittra Leardkamolkarn, PhD, Associate Professor, Department of Anatomy, Faculty of Science, Mahidol University, Rama Ⅵ Road, Bangkok 10400, Thailand. vijittra.lea@mahidol.ac.th
Key Words	Melatonin; Cisplatin; Hepatocellular carcinoma; excision repair cross complementary 1; mammalian target of rapamycin; Autophagy
Core Tip	Melatonin has anti-oxidative stress and anti-proliferative effects on cisplatin-treated hepatocellular carcinoma cells through a counter-balance between the roles of apoptosis and autophagy proteins. Melatonin also reduced cisplatin-induced DNA damage by decreasing the activation of excision repair cross complementary 1 in the DNA repair system. Thus, co-treatment with melatonin to ameliorate cisplatin adverse effects might be beneficial for Hepatocellular carcinoma therapy.
Publish Date	2014-05-20 15:05
Citation	Bennukul K, Numkliang S, Leardkamolkarn V. Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. World J Hepatol 2014; 6(4): 230-242
URL	http://www.wjgnet.com/1948-5182/full/v6/i4/230.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i4.230

Full Article (PDF)	WJH-6-230.pdf
Full Article (Word)	WJH-6-230.doc
Manuscript File	6653-Review.docx
Answering Reviewers	6653-Answering reviewers.pdf
Copyright License Agreement	6653-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6653-Language certificate.pdf
Peer-review Report	6653-Peer review(s).pdf
Scientific Editor Work List	6653-Scientific editor work list.doc