Publication Name	World Journal of Gastroenterology
Manuscript ID	6655
Country	Italy

Received	2013-10-26 12:24
Peer-Review Started	2013-10-27 12:24
To Make the First Decision	2014-01-09 12:33
Return for Revision	2014-01-11 19:17
Revised	2014-01-22 17:00
Second Decision	2014-02-27 11:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-27 11:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-26 11:19
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Inhibition of host immune response in colorectal cancer: Human leukocyte antigen-G and beyond
Manuscript Source	Invited Manuscript
All Author List	Marica Garziera and Giuseppe Toffoli
Funding Agency and Grant Number	Funding Agency Grant Number Associazione Italiana per la Ricerca sul Cancro (AIRC), Special Program Molecular Clinical Oncology, 5X1000 12214 (G.T.) European Research Council, Programme ‘‘Ideas’’, Proposal 269051 (G.T., F.R.)
Corresponding Author	Marica Garziera, PhD, Experimental and Clinical Pharmacology Unit, CRO Aviano National Cancer Institute, via Franco Gallini 2, 33081 Aviano, Italy. mgarziera@cro.it
Key Words	Colorectal cancer; Human leukocyte antigen-G; Immune score; T lymphocytes; Untranslated regions
Core Tip	Colorectal cancer (CRC) prognosis is strictly associated with the immune contexture of tumor microenvironment. IS improves prognostic prediction in CRC. Human leukocyte antigen-G (HLA-G) through its direct inhibitory functions on NK cells and cytotoxic T and B lymphocytes represents a crucial tumor-driven immune escape molecule. This review highlights the current knowledge on HLA-G in CRC and in related inflammatory diseases. HLA-G genetic setting and circulating/soluble profiles need to be defined to comprehend CRC strategies to avoid host immune defences. We suggest that HLA G could represent a novel prognostic immune biomarker to associate with the Immune Score to better characterize host immune response in CRC.
Publish Date	2014-04-14 10:49
Citation	Garziera M, Toffoli G. Inhibition of host immune response in colorectal cancer: Human leukocyte antigen-G and beyond. World J Gastroenterol 2014; 20(14): 3778-3794
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3778.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3778

Full Article (PDF)	WJG-20-3778.pdf
Full Article (Word)	WJG-20-3778.doc
Manuscript File	6655-Review.doc
Answering Reviewers	6655-Answering reviewers.pdf
Copyright License Agreement	6655-Copyright assignment.pdf
Peer-review Report	6655-Peer review(s).pdf
Scientific Editor Work List	6655-Scientific editor work list.doc