Publication Name	World Journal of Gastroenterology
Manuscript ID	6663
Country	Türkiye

Received	2013-10-26 16:50
Peer-Review Started	2013-10-27 12:58
To Make the First Decision	2014-01-09 12:32
Return for Revision	2014-01-11 19:24
Revised	2014-02-08 23:19
Second Decision	2014-05-26 16:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:38
Articles in Press	2014-05-26 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-04 15:22
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update
Manuscript Source	Invited Manuscript
All Author List	Gülsüm Özlem Elpek
Funding Agency and Grant Number
Corresponding Author	Gülsüm Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Pinarbasi Mh., 07070 Antalya, Turkey. elpek@akdeniz.edu.tr
Key Words	Liver; Liver fibrosis; Cirrhosis; Fibrogenesis; Hepatic stellate cells; Myofibroblast; Extracellular matrix
Core Tip	Liver fibrosis is a dynamic process that results from an imbalance between the production and dissolution of the extracellular matrix. Development of liver fibrosis is orchestrated by many cell types, including hepatic stellate cells (HSCs). The activation of HCSs is a complex process, leading to multiple potential sites for therapeutic interventions. Additionally, the differences between the pathogenesis of liver fibrosis associated with different etiologies may provide the determination of new therapeutic approaches. This review summarizes the most significant data that has contributed to the understanding of the cellular and molecular pathogenesis of liver fibrosis, which may be translated into future therapeutic strategies.
Publish Date	2014-06-21 13:56
Citation	Elpek GO. Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update. World J Gastroenterol 2014; 20(23): 7260-7276
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7260.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7260

Full Article (PDF)	WJG-20-7260.pdf
Full Article (Word)	WJG-20-7260.doc
Manuscript File	6663-Review.doc
Answering Reviewers	6663-Answering reviewers.pdf
Copyright License Agreement	6663-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6663-Language certificate.pdf
Peer-review Report	6663-Peer review(s).pdf
Scientific Misconduct Check	6663-CrossCheck.jpg
Scientific Editor Work List	6663-Scientific editor work list.pdf