Publication Name	World Journal of Biological Chemistry
Manuscript ID	66644
Country	United States

Received	2021-03-31 23:26
Peer-Review Started	2021-03-31 23:40
To Make the First Decision
Return for Revision	2021-06-07 02:47
Revised	2021-06-21 19:05
Second Decision	2021-08-03 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-03 08:38
Articles in Press	2021-08-03 08:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-18 02:00
Publish the Manuscript Online	2021-09-22 08:59

ISSN	1949-8454 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes
Manuscript Source	Invited Manuscript
All Author List	Colleen L O'Reilly, Selina Uranga and James D Fluckey
ORCID	Author(s) ORCID Number Colleen L O'Reilly http://orcid.org/0000-0002-9948-9410 Selina Uranga http://orcid.org/0000-0002-2250-6331 James D Fluckey http://orcid.org/0000-0003-1231-0412
Funding Agency and Grant Number
Corresponding Author	James D Fluckey, PhD, Professor, Health and Kinesiology, Texas A&M University, TAMU 4243, College Station, TX 77843, United States. jfluckey@tamu.edu
Key Words	Insulin resistance; Skeletal muscle; Mammalian target of rapamycin; Glucose uptake; Glucose regulation; Insulin signaling
Core Tip	The prevalence of type 2 diabetes (T2D) continues to rise despite the amount of research dedicated to finding the culprits of this debilitating disease. Within skeletal muscle there is a clear link to metabolic dysregulation during the progression of T2D but the determination of culprits vs consequences of the disease has been elusive. Emerging evidence in skeletal muscle implicates influential cross talk between the mammalian target of rapamycin (mTOR) complexes (mTORC1 and mTORC2) during insulin stimulated glucose uptake. This review highlights interactions between protein and glucose regulatory pathways and the implications this may have for the control of glucoregulatory function in skeletal muscle.
Publish Date	2021-09-22 08:59
Citation	O'Reilly CL, Uranga S, Fluckey JD. Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes. World J Biol Chem 2021; 12(5): 70-86
URL	https://www.wjgnet.com/1949-8454/full/v12/i5/70.htm
DOI	https://dx.doi.org/10.4331/wjbc.v12.i5.70

Full Article (PDF)	WJBC-12-70.pdf
Full Article (Word)	WJBC-12-70.docx
Manuscript File	66644_Auto_Edited-JPY.docx
Answering Reviewers	66644-Answering reviewers.pdf
Audio Core Tip	66644-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66644-Conflict-of-interest statement.pdf
Copyright License Agreement	66644-Copyright license agreement.pdf
Peer-review Report	66644-Peer-review(s).pdf
Scientific Misconduct Check	66644-Bing-Fan JR-2.png
Scientific Misconduct Check	66644-Scientific misconduct check.pdf
Scientific Editor Work List	66644-Scientific editor work list.pdf
CrossCheck Report	66644-CrossCheck report.pdf
CrossCheck Report	66644-CrossCheck.png