Publication Name	World Journal of Gastroenterology
Manuscript ID	6674
Country	Japan

Received	2013-10-26 17:23
Peer-Review Started	2013-10-27 13:27
To Make the First Decision	2014-01-09 12:29
Return for Revision	2014-01-11 19:35
Revised	2014-01-29 22:29
Second Decision	2014-04-09 08:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 08:58
Articles in Press	2014-05-23 10:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-29 11:48
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Methylation-mediated gene silencing as biomarkers of gastric cancer: A review
Manuscript Source	Invited Manuscript
All Author List	Jun Nakamura, Tomokazu Tanaka, Yoshihiko Kitajima, Hirokazu Noshiro and Kohji Miyazaki
Funding Agency and Grant Number
Corresponding Author	Jun Nakamura, MD, PhD, Department of Surgery, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan. nakamurj@cc.saga-u.ac.jp
Key Words	Gastric cancer; Methylation; Biomarker; Early detection; Drug sensitivity
Core Tip	This article summarizes the current understanding and recent evidence regarding DNA methylation markers in gastric cancer (GC) and includes our previous works. Current diagnostic and therapeutic tools of GC have not been successful in decreasing the global burden of this disease; however, it is promising that the early diagnosis and careful selection of patient subsets prior to initiating chemotherapy is a key factor for improving the outcomes of patients with GC. Methylation biomarkers would be useful for different purposes, including early detection, classification, assessment of the tumor prognosis, the development of therapeutic strategies and patient follow-up.
Publish Date	2014-09-18 19:50
Citation	Nakamura J, Tanaka T, Kitajima Y, Noshiro H, Miyazaki K. Methylation-mediated gene silencing as biomarkers of gastric cancer: a review. World J Gastroenterol 2014; 20(34): 11991-12006
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/11991.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.11991

Full Article (PDF)	WJG-20-11991.pdf
Full Article (Word)	WJG-20-11991.doc
Manuscript File	6674-Review.docx
Answering Reviewers	6674-Answering reviewers.pdf
Copyright License Agreement	6674-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6674-Language certificate.pdf
Peer-review Report	6674-Peer review(s).pdf
Scientific Editor Work List	6674-Scientific editor work list.doc