| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jeshua DeJesse, Ravy K Vajravelu, Christina Dudzik, Gillain Constantino, Jessica M Long, Kirk J Wangensteen, Kathleen D Valverde and Bryson W Katona |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
5R03DK120946-02 |
|
| Corresponding Author |
Bryson W Katona, MD, PhD, Assistant Professor, Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, 751 South Pavilion, Philadelphia, Pennsylvania 19104, United States. bryson.katona@pennmedicine.upenn.edu |
| Key Words |
Lynch syndrome; Urinary tract cancer; Intestinal neoplasms; Early diagnosis of cancer; Patient preference; Gastrointestinal surgical procedure |
| Core Tip |
This retrospective study of a Lynch syndrome (LS) cohort measured the uptake and outcome of small intestinal cancer (SIC) and urinary tract cancer (UTC) surveillance. When given the option of surveillance, a minority of patients elected surveillance, and patient completion of surveillance exams was suboptimal. Completed surveillance exams rarely detected SIC/UTC and resulted in multiple false positives that led to additional follow-up procedures. Pursuing and completing SIC/UTC surveillance in LS was influenced by several factors, however given the low yield and positive predictive value, broad incorporation of SIC/UTC surveillance in LS management is unlikely to be helpful. |
| Publish Date |
2021-11-19 09:32 |
| Citation |
DeJesse J, Vajravelu RK, Dudzik C, Constantino G, Long JM, Wangensteen KJ, Valverde KD, Katona BW. Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome. World J Clin Oncol 2021; 12(11): 1023-1036 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i11/1023.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i11.1023 |
