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Articles Published Processes
11/10/2021 7:13:09 AM | Browse: 799 | Download: 2191
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Received |
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2021-04-11 02:08 |
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Peer-Review Started |
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2021-04-11 02:10 |
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First Decision by Editorial Office Director |
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2021-05-24 04:06 |
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Return for Revision |
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2021-05-24 04:06 |
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Revised |
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2021-06-10 04:31 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-09-13 02:28 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-09-16 23:51 |
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Articles in Press |
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2021-09-16 23:51 |
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Edit the Manuscript by Language Editor |
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2021-10-20 19:18 |
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Typeset the Manuscript |
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2021-11-09 01:59 |
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Publish the Manuscript Online |
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2021-11-10 07:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Te-Sheng Chang, Kuo-Liang Wei, Wei-Ming Chen, Yi-Fang Deng, Chung-Kuang Lu, Yu-Hsuan Lai, Cheng-Shyong Wu and Chin Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0021 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0022 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0023 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0061 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0062 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0063 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0071 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0072 |
| Chiayi Chang Gung Memorial Hospital |
CORPG6G0073 |
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| Corresponding Author |
Chin Li, PhD, Associate Professor, Department of Biomedical Sciences, National Chung Cheng University, No. 168, Section 1, University Road, Minhsiung, Chiayi 62130, Taiwan. biocl@ccu.edu.tw |
| Key Words |
Fusobacterium nucleatum; Helicobacter pylori; Gastric cancer; Survival; Interferon; Mobility |
| Core Tip |
Fusobacterium nucleatum (F. nucleatum) is frequently enriched in the gastric cancer-associated microbiota. Here, we showed that F. nucleatum solicits a rapid but transient interferon response from gastric cancer cells. In addition, F. nucleatum leads to deregulation of the genes functioning in regulation of actin filament dynamics, likely changing cell mobility. In a patient cohort receiving gastrectomy, combined infection of F. nucleatum and Helicobacter pylori infection incurs poorer survival, indicating these two pathogens act synergistically to promote invasiveness of gastric cancer. Our finding suggests that F. nucleatum is a biomarker as treatment outcome predicator. |
| Publish Date |
2021-11-10 07:13 |
| Citation |
Hsieh YY, Tung SY, Pan HY, Chang TS, Wei KL, Chen WM, Deng YF, Lu CK, Lai YH, Wu CS, Li C. Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients. World J Gastroenterol 2021; 27(42): 7311-7323
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| URL |
https://www.wjgnet.com/1007-9327/full/v27/i42/7311.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i42.7311 |
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