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11/10/2021 7:13:09 AM | Browse: 290 | Download: 719
Publication Name World Journal of Gastroenterology
Manuscript ID 66800
Country/Territory Taiwan
Received
2021-04-11 02:08
Peer-Review Started
2021-04-11 02:10
To Make the First Decision
Return for Revision
2021-05-24 04:06
Revised
2021-06-10 04:31
Second Decision
2021-09-13 02:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-16 23:51
Articles in Press
2021-09-16 23:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-10-20 19:18
Typeset the Manuscript
2021-11-09 01:59
Publish the Manuscript Online
2021-11-10 07:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients
Manuscript Source Unsolicited Manuscript
All Author List Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Te-Sheng Chang, Kuo-Liang Wei, Wei-Ming Chen, Yi-Fang Deng, Chung-Kuang Lu, Yu-Hsuan Lai, Cheng-Shyong Wu and Chin Li
ORCID
Author(s) ORCID Number
Yung-Yu Hsieh http://orcid.org/0000-0001-8465-5204
Shui-Yi Tung http://orcid.org/0000-0002-8399-4754
Hung-Yu Pan http://orcid.org/0000-0002-4036-3047
Te-Sheng Chang http://orcid.org/0000-0002-1581-6948
Kuo-Liang Wei http://orcid.org/0000-0002-7209-5411
Wei-Ming Chen http://orcid.org/0000-0002-4949-393X
Yi-Fang Deng http://orcid.org/0000-0003-0093-4228
Chung-Kuang Lu http://orcid.org/0000-0002-3688-5002
Yu-Hsuan Lai http://orcid.org/0000-0002-8576-2236
Cheng-Shyong Wu http://orcid.org/0000-0002-5917-2400
Chin Li http://orcid.org/0000-0002-5457-9623
Funding Agency and Grant Number
Funding Agency Grant Number
Chiayi Chang Gung Memorial Hospital CORPG6G0021
Chiayi Chang Gung Memorial Hospital CORPG6G0022
Chiayi Chang Gung Memorial Hospital CORPG6G0023
Chiayi Chang Gung Memorial Hospital CORPG6G0061
Chiayi Chang Gung Memorial Hospital CORPG6G0062
Chiayi Chang Gung Memorial Hospital CORPG6G0063
Chiayi Chang Gung Memorial Hospital CORPG6G0071
Chiayi Chang Gung Memorial Hospital CORPG6G0072
Chiayi Chang Gung Memorial Hospital CORPG6G0073
Corresponding Author Chin Li, PhD, Associate Professor, Department of Biomedical Sciences, National Chung Cheng University, No. 168, Section 1, University Road, Minhsiung, Chiayi 62130, Taiwan. biocl@ccu.edu.tw
Key Words Fusobacterium nucleatum; Helicobacter pylori; Gastric cancer; Survival; Interferon; Mobility
Core Tip Fusobacterium nucleatum (F. nucleatum) is frequently enriched in the gastric cancer-associated microbiota. Here, we showed that F. nucleatum solicits a rapid but transient interferon response from gastric cancer cells. In addition, F. nucleatum leads to deregulation of the genes functioning in regulation of actin filament dynamics, likely changing cell mobility. In a patient cohort receiving gastrectomy, combined infection of F. nucleatum and Helicobacter pylori infection incurs poorer survival, indicating these two pathogens act synergistically to promote invasiveness of gastric cancer. Our finding suggests that F. nucleatum is a biomarker as treatment outcome predicator.
Publish Date 2021-11-10 07:13
Citation Hsieh YY, Tung SY, Pan HY, Chang TS, Wei KL, Chen WM, Deng YF, Lu CK, Lai YH, Wu CS, Li C. Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients. World J Gastroenterol 2021; 27(42): 7311-7323
URL https://www.wjgnet.com/1007-9327/full/v27/i42/7311.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i42.7311
Full Article (PDF) WJG-27-7311.pdf
Full Article (Word) WJG-27-7311.docx
Manuscript File 66800-Review-Filipodia-CL.docx
Answering Reviewers 66800-Answering reviewers.pdf
Audio Core Tip 66800-Audio core tip.m4a
Biostatistics Review Certificate 66800-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66800-Conflict-of-interest_statement.pdf
Copyright License Agreement 66800-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 66800-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 66800-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 66800-Language certificate.pdf
Peer-review Report 66800-Peer-review(s).pdf
Scientific Misconduct Check 66800-Bing-Wang JL-1.jpg
Scientific Misconduct Check 66800-Bing-Wu YXJ-2.jpg
Scientific Editor Work List 66800-Scientific editor work list.pdf