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Articles Published Processes
8/23/2022 9:54:46 AM | Browse: 271 | Download: 698
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Received |
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2021-04-07 16:24 |
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Peer-Review Started |
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2021-04-07 16:28 |
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To Make the First Decision |
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Return for Revision |
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2021-06-28 08:43 |
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Revised |
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2021-08-08 18:59 |
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Second Decision |
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2022-07-13 02:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-18 00:14 |
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Articles in Press |
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2022-07-18 00:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-09 04:05 |
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Typeset the Manuscript |
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2022-08-17 09:34 |
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Publish the Manuscript Online |
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2022-08-23 09:54 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Prospective Study |
| Article Title |
Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ern-Yu Tan, Lavina Bharwani, Yee-Hong Chia, Richie C T Soong, Sherylyn S Y Lee, Juliana J C Chen and Patrick M Y Chan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NHG-KTPH Small Innovative Grants (SIG) |
SIG/11009 |
| NHG-KTPH Small Innovative Grants (SIG) |
SIG/15025 |
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| Corresponding Author |
Ern-Yu Tan, DPhil, FRCS (Gen Surg), MBBS, Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. ern_yu_tan@ttsh.com.sg |
| Key Words |
Functional cytochrome P450 2D6 polymorphisms; Breast cancer; Hormonal therapy |
| Core Tip |
We studied the role of cytochrome P450 2D6 (CYP2D6) polymorphisms in guiding the selection of hormonal agents in women with hormone-responsive breast cancer. The CYP2D6 intermediate metabolizer phenotype was highly prevalent in our women, while the poor metabolizer phenotype was rare. We did not observe any significant association between the CYP2D6 phenotypes and recurrence-free or overall survival in our study, although it could be because most women opted for aromatase inhibitors regardless of CYP2D6 phenotype. There was a non-significant trend towards better survival associated with aromatase inhibitor use over tamoxifen. |
| Publish Date |
2022-08-23 09:54 |
| Citation |
Tan EY, Bharwani L, Chia YH, Soong RCT, Lee SSY, Chen JJC, Chan PMY. Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer. World J Clin Oncol 2022; 13(8): 712-724 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i8/712.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i8.712 |
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