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Articles Published Processes
8/25/2021 2:11:51 AM | Browse: 367 | Download: 899
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Received |
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2021-04-07 15:21 |
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Peer-Review Started |
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2021-04-07 15:22 |
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To Make the First Decision |
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Return for Revision |
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2021-05-27 20:33 |
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Revised |
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2021-06-06 02:35 |
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Second Decision |
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2021-07-19 03:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-20 08:00 |
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Articles in Press |
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2021-07-20 08:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-28 20:44 |
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Typeset the Manuscript |
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2021-08-23 01:52 |
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Publish the Manuscript Online |
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2021-08-25 02:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Therapeutic effect of Cistanche deserticola on defecation in senile constipation rat model through stem cell factor/C-kit signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xia Zhang, Fa-Juan Zheng and Zhen Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Chongqing |
cstc2017jcyjAX0306 |
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| Corresponding Author |
Zhen Zhang, MD, Deputy Director, Department of Anorectal, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Seventh Branch of Panxi Road, Jiangbei District, Chongqing 400021, China. zhangzhen@cdutcm.edu.cn |
| Key Words |
Cistanche deserticola; Senile constipation; Stem cell factors; C-kit |
| Core Tip |
This study attempted to find a possible mechanism of Cistanche deserticola (C. deserticola) in the treatment of constipation. The mechanism might be proving colon motility through stem cell factor (SCF)/C-kit signaling pathway in colon Cajal stromal cells. Therefore, the constipation rat model was replicated, and then rats were treated by direct administration of C. deserticola and specific blocking of the SCF/C-kit signaling pathway. The defecation of rats, changes of colonic pathology and ultrastructure as well as the protein expression related to SCF/C-kit signaling pathway were observed. Our results support that the SCF/C-kit signaling pathway plays an important mechanism of the therapeutic effect of C. deserticola. |
| Publish Date |
2021-08-25 02:11 |
| Citation |
Zhang X, Zheng F, Zhang Z. Therapeutic effect of Cistanche deserticola on defecation in senile constipation rat model through stem cell factor/C-kit signaling pathway. World J Gastroenterol 2021; 27(32): 5392-5403 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i32/5392.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i32.5392 |
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